Extended-Release Formulations for the Treatment of Epilepsy

被引：0
作者：
Meir Bialer
机构：
[1] School of Pharmacy,Department of Pharmaceutics
[2] Faculty of Medicine,David R. Bloom Center for Pharmacy, Faculty of Medicine
[3] The Hebrew University of Jerusalem,undefined
[4] The Hebrew University of Jerusalem,undefined
来源：
CNS Drugs | 2007年 / 21卷
关键词：
Valproic Acid; Oxcarbazepine; Sodium Valproate; Divalproex Sodium; Tegretol;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This review analyses the concept of extended-release (ER) formulations in epilepsy and evaluates ER formulations of carbamazepine, valproic acid and a modified-release (MR) formulation of oxcarbazepine. ER formulations are usually designed to reduce dose frequency and maintain relatively constant or flat plasma drug concentration. It is questionable whether flat plasma concentrations of an antiepileptic drug (AED) improve antiepileptic efficacy compared with fluctuating plasma concentrations. More certainly, they minimise concentration-related adverse effects, and the dosing flexibility and consistency of plasma concentrations may simplify the management of antiepileptic drug therapy.
引用
收藏
页码：765 / 774
页数：9
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