Prognostic roles of time to positivity of blood culture in children with Streptococcus pneumoniae bacteremia

被引：0
作者：
Qinyuan Li
Yuanyuan Li
Qian Yi
Fengtao Suo
Yuan Tang
Siying Luo
Xiaoyin Tian
Guangli Zhang
Dapeng Chen
Zhengxiu Luo
机构：
[1] Key Laboratory of Pediatrics in Chongqing,Department of Respiratory Medicine
[2] Department of Children’s Hospital of Chongqing Medical University of Education Key Laboratory of Child Development and Disorders,Department of Clinical Laboratory center
[3] Children’s Hospital of Chongqing Medical University,undefined
[4] Children’s Hospital of Chongqing Medical University,undefined
来源：
European Journal of Clinical Microbiology & Infectious Diseases | 2019年 / 38卷
关键词：
Time to positivity; Blood culture; Bacteremia; Outcomes; Children;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We aimed to investigate the relationship between time to positivity (TTP) of blood cultures and clinical outcomes in children with S. pneumoniae bacteremia. Children with S. pneumoniae bacteremia hospitalized in Children’s Hospital of Chongqing Medical University from May 2011 to December 2017 were enrolled retrospectively. Overall, 136 children with S. pneumoniae bacteremia were enrolled. The standard cutoff TTP was 12 h. We stated that in-hospital mortality is significantly higher in the early TTP (≤ 12 h) group than that in the late TTP (> 12 h) group (41.70% vs 8.00%, P < 0.001). Septic shock occurred in 58.30% of patients with early TTP and in 21.00% of patients with late TTP (P < 0.001). Independent risk factors of in-hospital mortality and septic shock in children with S. pneumoniae bacteremia included early TTP, need for invasive mechanical ventilation, and PRISM III score ≥ 10. Overall, TTP ≤ 12 h appeared to associate with the worse outcomes for children with S. pneumoniae bacteremia.
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页码：457 / 465
页数：8
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