Modeling the mechanism pathways of first line drug in Tuberculosis using Petri nets

Multi-Drug Resistant (MDR) and Extensively Drug-Resistant (XDR) in Tuberculosis (TB) is still a big threat worldwide, as it remains one of the leading causes of death. The main reason behind this is the Mycobacterium tuberculosis bacteria (Mtb) is being resistant towards first line drug (FLD). This is because of the mutation in certain genes like katG, pncA, rpoB, embABC. To have a better understanding of the mechanism behind the susceptibility and resistivity of drugs involved in FLD, we propose a graphical approach of modeling the whole process by using Petri net. The analysis of the model helps in improving the new drug techniques on the way to decrease the rate of MDR-TB and XDR-TB.