A methodological survey of the analysis, reporting and interpretation of Absolute Risk ReductiOn in systematic revieWs (ARROW): A study protocol

被引：12

作者：

Alonso-Coello P. ^{[1
,2
]}

Carrasco-Labra A. ^{[2
,3
]}

Brignardello-Petersen R. ^{[2
,3
]}

Neumann I. ^{[2
,4
]}

Akl E.A. ^{[2
,5
,6
]}

Sun X. ^{[2
,7
]}

Johnston B.C. ^{[2
,8
,9
]}

Briel M. ^{[10
]}

Busse J.W. ^{[2
,11
]}

Glujovsky D. ^{[12
]}

Granados C.E. ^{[13
]}

Iorio A. ^{[2
]}

Irfan A. ^{[14
]}

García L.M. ^{[1
]}

Mustafa R.A. ^{[15
]}

Ramirez-Morera A. ^{[16
]}

Solà I. ^{[1
]}

Tikkinen K.A.O. ^{[2
,17
]}

Ebrahim S. ^{[2
,11
,18
]}

Vandvik P.O. ^{[19
]}

Zhang Y. ^{[2
]}

Selva A. ^{[1
]}

Sanabria A.J. ^{[1
]}

Zazueta O.E. ^{[1
]}

Vernooij R.W.M. ^{[1
]}

Schünemann H.J. ^{[2
]}

Guyatt G.H. ^{[2
]}

机构：

[1] Institute of Biomedical Research (IIB-Sant Pau), Iberoamerican Cochrane Centre, Barcelona

[2] McMaster University, Department of Clinical Epidemiology and Biostatistics, Hamilton

[3] Universidad de Chile, Evidence-Based Dentistry Unit, Faculty of Dentistry, Santiago

[4] Pontificia Universidad Católica de Chile, Department of Medicine, Santiago

[5] American University of Beirut, Department of Internal Medicine, Beirut

[6] State University of New York, Department of Medicine, Buffalo, NY

[7] Sichuan University, Chinese Evidence-based Medicine Centre, West China Hospital, Chengdu

[8] University of Toronto, Department of Anaesthesia and Pain Medicine, The Hospital for Sick Children, Institute of Health Policy, Management and Evaluation, Toronto, ON

[9] The Hospital for Sick Children Research Institute, Child Health Evaluative Sciences, Toronto, ON

[10] University Hospital Basel, Basel Institute for Clinical Epidemiology and Biostatistics, Basel

[11] McMaster University, Department of Anaesthesia, Hamilton

[12] Argentine Cochrane Centre IECS (Institute for Clinical Effectiveness and Health Policy), Buenos Aires

[13] Universidad de La Sabana, Área de investigaciones, Facultad de Medicina, Chía

[14] University of Illinois, Internal Medicine Residency Program, Urbana-Champaign, IL

[15] University Of Missouri-Kansas City, Department of Medicine and Nephrology, Missouri-Kansas City, MO

[16] IHCAI Foundation and Central America Cochrane, CCSS Permanent Medical Advisor, Health Care Development Division, Costa Rica

[17] Helsinki University Central Hospital and University of Helsinki, Department of Urology, Helsinki

[18] University of Toronto, Institute of Health Policy, Management and Evaluation, Toronto

[19] Norwegian Knowledge Centre for the Health Services, Oslo

来源：

Systematic Reviews | / 2卷 / 1期

基金：

加拿大健康研究院;

关键词：

Absolute effect measures; Data reporting; Evidence-based medicine; Meta-analysis; Numbers needed to treat; Statistical data; Systematic reviews;

D O I：

10.1186/2046-4053-2-113

中图分类号：

学科分类号：

摘要：

Background: Clinicians, providers and guideline panels use absolute effects to weigh the advantages and downsides of treatment alternatives. Relative measures have the potential to mislead readers. However, little is known about the reporting of absolute measures in systematic reviews. The objectives of our study are to determine the proportion of systematic reviews that report absolute measures of effect for the most important outcomes, and ascertain how they are analyzed, reported and interpreted. Methods/design: We will conduct a methodological survey of systematic reviews published in 2010. We will conduct a 1:1 stratified random sampling of Cochrane vs. non-Cochrane systematic reviews. We will calculate the proportion of systematic reviews reporting at least one absolute estimate of effect for the most patient-important outcome for the comparison of interest. We will conduct multivariable logistic regression analyses with the reporting of an absolute estimate of effect as the dependent variable and pre-specified study characteristics as the independent variables. For systematic reviews reporting an absolute estimate of effect, we will document the methods used for the analysis, reporting and interpretation of the absolute estimate. Discussion: Our methodological survey will inform current practices regarding reporting of absolute estimates in systematic reviews. Our findings may influence recommendations on reporting, conduct and interpretation of absolute estimates. Our results are likely to be of interest to systematic review authors, funding agencies, clinicians, guideline developers and journal editors. © 2013 Alonso-Coello et al.; licensee BioMed Central Ltd.

引用

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