Tricyclics vs SSRIs for postpartum depression

被引：0

作者：

Wisner K.L. ^{[1
,2
]}

Peindl K.S. ^{[1
]}

Gigliotti T.V. ^{[1
]}

机构：

[1] Case Western Reserve University, School of Medicine, Women's Services, Cleveland, OH

[2] Women's Program, Case Western Reserve University, School of Medicine, 11400 Euclid Avenue, Cleveland

来源：

Archives of Women's Mental Health | 1999年 / 1卷 / 4期

关键词：

Antidepressants; Postpartum depression; Serotonin specific reuptake inhibitors; Tricyclics;

D O I：

10.1007/s007370050027

中图分类号：

学科分类号：

摘要：

Background: We investigated whether differential responsivity to tricyclics (TCA) compared to serotonin specific reuptake inhibitors (SSRI) occurred in our clinical population of women with postpartum depression. Method: Sequential records (N = 35) of women with non-psychotic, non-bipolar, postparrum-onset major depression were reviewed to determine drug response. Response was defined as 50% reduction in the initial depression score by week 8 of treatment. Results: The response rate was 67% for TCA was 79% for SSRI. The five nonresponders to TCA were treated with an SSRI, and four (80%) were effectively treated. Discussion: This naturalistic data obtained from our clinic supports that SSRI are superior to TCA for the treatment of postpartum major depression. The difference in percent response (12%) is similar to that of other studies in which TCA were compared to SSRI for treatment depression in women.

引用

页码：189 / 191

页数：2

共 16 条

[1]

Bromberger, J., Wisner, K.L., Hanusa, B.H., Psychosocial correlates of nonremisson of treated depression: A prospective pilot study of mothers of infants and toddlers (1993) J Nerv Ment Dis, 181, pp. 41-45

[2]

Dean, C., Kendell, R.E., The symptomatology of puerperal illnesses (1981) Br J Psychiatry, 139, pp. 128-135

[3]

Elkin, I., Shea, M.T., Watkins, J.T., General effectiveness of treatments (1989) Arch Gen Psychiatry, 46, pp. 971-982. , National Institute of Mental Health Treatment of Depression Collaborative Research Program

[4]

Epperson, C.N., Anderson, G.M., McDougle, C.J., Sertraline and beastfeeding (1997) NEJM, 336, pp. 1189-1190

[5]

Freeman, E.W., Rickels, K., Sondheimer, S.J., Wittmaack, F.M., Sertraline versus desipramine in the treatment of premenstrual syndrome: An open-label trial (1996) J Clin Psychiatry, 57, pp. 7-11

[6]

Hamilton, M., A rating scale for depression (1960) J Neurol Neurosurg Psychiatry, 23, pp. 56-62

[7]

Kornstein, S., Premenstrual exacerbation of depression (1996) Annual Meeting of the American Psychiatric Association, , New York

[8]

Pearlstein, T.B., Stone, A.B., Long-term fluoxetine treatment of late luteal phase dysphoric disorder (1994) J Clin Psychiatry, 52, pp. 332-335

[9]

Stowe, Z.N., Casarella, J., Landry, J., Nemeroff, C.B., Sertraline in the treatment of women with postpartum major depression (1995) Depression, 3, pp. 49-55

[10]

Stowe, Z.N., Owens, M.J., Landry, J.C., Kilts, C.D., Ely, T., Llewellyn, B.A., Nemeroff, C.B., Sertraline and desmethylsertraline in human breast milk and nursing infants (1997) Am J Psychiatry, 154, pp. 1255-1260

← 1 2 →