Questioning the use of PEGylation for drug delivery

被引：0
作者：
Johan J. F. Verhoef
Thomas J. Anchordoquy
机构：
[1] University of Utrecht,School of Pharmacy and Pharmaceutical Sciences
[2] University of Colorado Denver,Skaggs School of Pharmacy and Pharmaceutical Sciences
来源：
Drug Delivery and Translational Research | 2013年 / 3卷
关键词：
Polyethylene glycol; PEG; Transfection; DNA; RNA; Drug delivery; Immunogenicity; Stealth;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Polyethylene glycol (PEG) is widely utilized in drug delivery and nanotechnology due to its reported “stealth” properties and biocompatibility. It is generally thought that PEGylation allows particulate delivery systems and biomaterials to evade the immune system and thereby prolong circulation lifetimes. However, numerous studies over the past decade have demonstrated that PEGylation causes significant reductions in drug delivery, including enhanced serum protein binding, reduced uptake by target cells, and the elicitation of an immune response that facilitates clearance in vivo. This report reviews some of the extensive literature documenting the detrimental effects of PEGylation, and thereby questions the wisdom behind employing this strategy in drug development.
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页码：499 / 503
页数：4
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