Inhibition of In Vitro Metabolism of Simvastatin by Itraconazole in Humans and Prediction of In Vivo Drug-Drug Interactions

被引：0
作者：
Michi Ishigam
Minoru Uchiyama
Tomoko Kondo
Haruo Iwabuchi
Shin-ichi Inoue
Wataru Takasaki
Toshihiko Ikeda
Toru Komai
Kiyomi Ito
Yuichi Sugiyama
机构：
[1] Sankyo Co.,Drug Metabolism and Pharmacokinetics Research Laboratories and Product Strategy Department
[2] Ltd.,School of Pharmaceutical Sciences
[3] Kitasato University,Graduate School of Pharmaceutical Sciences
[4] University of Tokyo,undefined
来源：
Pharmaceutical Research | 2001年 / 18卷
关键词：
drug-drug interaction; CYP3A4; HMG-CoA reductase inhibitor; simvastatin; pravastatin; itraconazole;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. To evaluate an interaction between simvastatin and itraconazole in in vitro studies and to attempt a quantitative prediction of in vivo interaction in humans.
引用
收藏
页码：622 / 631
页数：9
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