Voltammetric determination of phentolamine mesylate in pharmaceutical formulations at poly (4-aminobenzene sulfonic acid)-modified glassy carbon electrode

被引：0
作者：
Sen Fan
Lei Ji
Guoliang Mao
Xin Sui
Huan Wang
Yuanhai Zhu
Hua Song
机构：
[1] Northeast Petroleum University,College of Petroleum Engineering
[2] Northeast Petroleum University,College of Chemistry and Chemical Engineering
来源：
Chemical Papers | 2020年 / 74卷
关键词：
Phentolamine; Electropolymerization; 4-Aminobenzene sulfonic acid; Modified glassy carbon electrode;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A poly (4-aminobenzene sulfonic acid)-modified glassy carbon electrode (p-ABSA/GCE) was fabricated by electropolymerization. It was found that phentolamine mesylate, an effective and important cardiovascular dilatation drug with low redox activity at the glassy carbon electrode (GCE) can produce a sensitive well-defined anodic peak current at p-ABSA/GCE. Investigation indicated that the oxidation of phentolamine at p-ABSA/GCE was one electron/one proton transfer process which was controlled by adsorption. In optimal conditions, the anodic peak current was linear to the concentrations of phentolamine over the range of 5.0 × 10–7–1.0 × 10–5 M with a detection limit of 2.0 × 10–7 M. The modified electrode showed good stability and reproducibility. The electroanalytical method proposed was successfully applied to the determination of phentolamine mesylate in pharmaceutical formulations.
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页码：4411 / 4417
页数：6
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