Mammography screening and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a prospective study

被引：0

作者：

Vasily Giannakeas

Jan Lubinski

Jacek Gronwald

Pal Moller

Susan Armel

Henry T. Lynch

William D. Foulkes

Charmaine Kim-Sing

Christian Singer

Susan L. Neuhausen

Eitan Friedman

Nadine Tung

Leigha Senter

Ping Sun

Steven A. Narod

机构：

[1] University of Toronto,Dalla Lana School of Public Health

[2] Women’s College Research Institute,Familial Breast Cancer Research Unit

[3] Pomeranian Medical University,International Hereditary Cancer Center, Department of Genetics and Pathology

[4] Oslo University Hospital,Research Group Inherited Cancer, Department of Medical Genetics

[5] University of Toronto,Department of Obstetrics and Gynecology

[6] Creighton University School of Medicine,Department of Preventative Medicine and Public Health

[7] McGill University,McGill Program in Cancer Genetics, Departments of Oncology and Human Genetics

[8] BC Cancer Agency,Department of Obstetrics and Gynecology and Comprehensive Cancer Center

[9] Medical University of Vienna,Department of Population Sciences

[10] Beckman Research Institute of City of Hope,The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center and the Sackler School of Medicine

[11] Tel-Aviv University,Division of Human Genetics

[12] Beth Israel Deaconess Medical Center,undefined

[13] The Ohio State University Medical Center,undefined

[14] Comprehensive Cancer Care,undefined

来源：

Breast Cancer Research and Treatment | 2014年 / 147卷

关键词：

BRCA1; BRCA2; Mammography; Breast cancer;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Women with a genetic predisposition to breast cancer may be at increased risk of cancer after exposure to ionizing radiation. It is unclear whether mammography screening increases the risk of breast cancer among BRCA1 and BRCA2 carriers. We identified 2,346 women with a BRCA1 (n = 1844) or BRCA2 (n = 502) mutation and no breast cancer, and we reviewed their history of mammography exposure. These women were followed for an average of 5.3 years and were observed for new breast cancer diagnoses. At study entry, 1808 women (77.1 %) reported ever having had a mammogram; of these, 204 women (11.2 %) reported having had a mammogram before age 30. We estimated the hazard ratios for the development of invasive breast cancer, conditional on the number of prior mammograms and on the age at first mammogram. Hazard ratios were estimated and stratified by gene (BRCA1 or BRCA2), relative to women with no exposure. We observed no significant association between prior mammography exposure and breast cancer risk for BRCA1 carriers (HR 0.79; 95 % CI 0.53–1.19; P = 0.26) or for BRCA2 carriers (HR 0.90; 95 % CI 0.35–2.34; P = 0.83). An early age at first mammogram (<30 years) did not increase breast cancer risk among BRCA1 carriers (HR 0.75; 95 % CI 0.41–1.37; P = 0.35) or among BRCA2 carriers (HR 0.69; 95 % CI 0.19–2.48; P = 0.57). Exposure to mammography in women with BRCA1 and BRCA2 mutations is not associated with an increased risk of breast cancer.

引用

页码：113 / 118

页数：5

共 42 条

[1] Antoniou A(2003)Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies Am J Hum Genet 72 1117-1130
[2] Pharoah PDP(2012)Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK) BMJ 345 e5660-938
[3] Narod S(2011)Variation in breast cancer risk with mutation position, smoking alcohol, and chest X-ray history, in the French National BRCA1/2 carrier cohort (GENEPSO) Breast Cancer Res Treat 130 927-584
[4] Pijpe A(2008)Early radiation exposures and BRCA1-associated breast cancer in young women from Poland Breast Cancer Res Treat 112 581-3366
[5] Andrieu N(2006)Effect of chest X-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the international BRCA1/2 carrier cohort study: a report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators’ Group J Clin Oncol 24 3361-352
[6] Easton DF(2006)The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the breast cancer family registry Cancer Epidemiol Biomark Prev 15 348-2334
[7] LeCarpentier J(2005)Polymorphisms in DNA repair genes, medical exposure to ionizing radiation, and breast cancer risk Cancer Epidemiol Biomark Prev 14 2326-1556
[8] Nogues C(2013)Diagnostic chest X-rays and breast cancer risk before age 50 years for BRCA1 and BRCA2 mutation carriers Cancer Epidemiol Biomarkers Prev 22 1547-394
[9] Mouret-Fourme E(2007)Medical radiation exposure and breast cancer risk: findings from the breast cancer family registry Int J Cancer 121 386-406
[10] Gronwald J(2006)Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study Lancet Oncol 7 402-2313

← 1 2 3 4 5 →