Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis

被引：10

作者：

He K. ^{[1
,2
]}

Ma Y.-B. ^{[1
]}

Geng C.-A. ^{[1
]}

Zhang X.-M. ^{[1
]}

Cao T.-W. ^{[1
,2
]}

Jiang F.-Q. ^{[1
,2
]}

Chen J.-J. ^{[1
]}

机构：

[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming

[2] Graduate University of Chinese Academy of Sciences, Beijing

来源：

Natural Products and Bioprospecting | 2011年 / 1卷 / 1期

关键词：

anti-HBV activity; Swertia kouitchensis; swertiakoside A; swertiakoside B; swertiakoulactone;

D O I：

10.1007/s13659-011-0009-5

中图分类号：

学科分类号：

摘要：

Three new secoiridoids, swertiakoulactone (1) and swertiakosides A and B (2 and 3), were isolated from Swertia kouitchensis. Their structures were elucidated by comprehensive spectroscopic analyses including MS, IR, 1D and 2D NMR data. By the anti-hepatitis B virus (HBV) assay on Hep G 2.2.15 cells line in vitro, compound 1 showed moderate activities inhibiting the HBsAg secretion (IC50 = 1.10 mM, SI = 4.39) and HBV DNA replication (IC50 = 1.16 mM, SI = 4.12). [Figure not available: see fulltext.]. © 2011, The Author(s).

引用

页码：48 / 51

页数：3

共 50 条

[41] Anti-Hepatitis B Virus Activity of Esculetin from Microsorium fortunei In Vitro and In Vivo
Huang, Si-Xin
Mou, Jun-Fei
Luo, Qin
Mo, Qing-Hu
Zhou, Xian-Li
Huang, Xiao
Xu, Qing
Tan, Xiang-Duan
Chen, Xu
Liang, Cheng-Qin
MOLECULES, 2019, 24 (19):
[42] Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim
Xu, Hong-Yan
Ren, Ji-Hua
Su, Yu
Ren, Fang
Zhou, Yu-Jiao
Jiang, Hui
Cheng, Sheng-Tao
Zhang, Chuan-Rui
Chen, Juan
JOURNAL OF ETHNOPHARMACOLOGY, 2020, 257
[43] Novel anti-hepatitis B virus flavonoids sakuranetin and velutin from Rhus retinorrhoea
Ahmed, Sarfaraz
Parvez, Mohammad K.
Al-Dosari, Mohammed S.
Abdelwahid, Mazin A. S.
Alhowiriny, Tawfeq A.
Al-Rehaily, Adnan J.
MOLECULAR MEDICINE REPORTS, 2023, 28 (03)
[44] Lignans with Anti-Hepatitis B Virus Activities from Phyllanthus niruri L.
Wei, Wanxing
Li, Xiangrong
Wang, Kuiwu
Zheng, Zuowen
Zhou, Min
PHYTOTHERAPY RESEARCH, 2012, 26 (07) : 964 - 968
[45] Anti-hepatitis B Virus Activities of Astragaloside IV Isolated from Radix Astragali
Wang, Shuguang
Li, Jiyang
Huang, Hai
Gao, Wen
Zhuang, Changlong
Li, Bo
Zhou, Pei
Kong, Deyun
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2009, 32 (01) : 132 - 135
[46] Anti-hepatitis B virus effects of the traditional Chinese herb Arteinisia capillaris and its active enynes
Geng, Chang-An
Yang, Tong-Hua
Huang, Xiao-Yan
Yang, Jing
Ma, Yun-Bao
Li, Tian-Ze
Zhang, Xue-Mei
Chen, Ji-Jun
JOURNAL OF ETHNOPHARMACOLOGY, 2018, 224 : 283 - 289
[47] Anti-hepatitis B virus activities of Geranium carolinianum L. extracts and identification of the active components
Li, Jiyang
Huang, Hai
Zhou, Wei
Feng, Meiqing
Zhou, Pei
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2008, 31 (04) : 743 - 747
[48] New anti-hepatitis B virus drugs under development and evaluation
Pan, Jiaqian
Tong, Shuangmei
Kang, Lei
Tang, Jing
CURRENT OPINION IN INFECTIOUS DISEASES, 2016, 29 (06) : 632 - 638
[49] Studies on the Screening of Novel Anti-hepatitis B Virus (HBV) Drugs
Kojima, Soichi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2017, 133 (03) : S21 - S21
[50] In Vitro Anti-hepatitis B Virus Activity of 2',3'-Dideoxyguanosine
Pinghu Zhang
Shuo Zhai
Jinhong Chang
Ju-Tao Guo
Virologica Sinica, 2018, (06) : 538 - 544

← 1 2 3 4 5 →