Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis

被引：10
|
作者：
He K. [1 ,2 ]
Ma Y.-B. [1 ]
Geng C.-A. [1 ]
Zhang X.-M. [1 ]
Cao T.-W. [1 ,2 ]
Jiang F.-Q. [1 ,2 ]
Chen J.-J. [1 ]
机构：
[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming
[2] Graduate University of Chinese Academy of Sciences, Beijing
来源：
Natural Products and Bioprospecting | 2011年 / 1卷 / 1期
关键词：
anti-HBV activity; Swertia kouitchensis; swertiakoside A; swertiakoside B; swertiakoulactone;
D O I：
10.1007/s13659-011-0009-5
中图分类号：
学科分类号：
摘要：
Three new secoiridoids, swertiakoulactone (1) and swertiakosides A and B (2 and 3), were isolated from Swertia kouitchensis. Their structures were elucidated by comprehensive spectroscopic analyses including MS, IR, 1D and 2D NMR data. By the anti-hepatitis B virus (HBV) assay on Hep G 2.2.15 cells line in vitro, compound 1 showed moderate activities inhibiting the HBsAg secretion (IC50 = 1.10 mM, SI = 4.39) and HBV DNA replication (IC50 = 1.16 mM, SI = 4.12). [Figure not available: see fulltext.]. © 2011, The Author(s).
引用
收藏
页码：48 / 51
页数：3
相关论文
共 50 条
  • [21] Investigation of Anti-Hepatitis Delta Virus and Anti- Hepatitis C Virus in Patients with Hepatitis B Virus Infection
    Inci, Ayse
    Fincanci, Muzaffer
    Muderrisoglu, Cuneyt
    ISTANBUL MEDICAL JOURNAL, 2013, 14 (02): : 109 - 111
  • [22] Sesquiterpenes from the fruits of Illicium jiadifengpi and their anti-hepatitis B virus activities
    Liu, Ji-Feng
    Wang, Lei
    Wang, Ya-Feng
    Song, Xu
    Yang, Li-Jia
    Zhang, Yan-Bing
    FITOTERAPIA, 2015, 104 : 41 - 44
  • [23] Anti-hepatitis B virus constituents from the stem bark of Streblus asper
    Li, Jun
    Huang, Yan
    Guan, Xin-Lan
    Li, Jian
    Deng, Sheng-Ping
    Wu, Qiang
    Zhang, Yan-Jun
    Su, Xiao-Jian
    Yang, Rui-Yun
    PHYTOCHEMISTRY, 2012, 82 : 100 - 109
  • [24] Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species
    Chiang, LC
    Ng, LT
    Liu, LT
    Shieh, DE
    Lin, CC
    PLANTA MEDICA, 2003, 69 (08) : 705 - 709
  • [25] Anti-hepatitis B virus activities of friedelolactones from Viola diffusa Ging
    Dai, Jiao-Jiao
    Tao, Hua-Ming
    Min, Qing-Xi
    Zhu, Quan-Hong
    PHYTOMEDICINE, 2015, 22 (7-8) : 724 - 729
  • [26] Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis
    Huang, RL
    Chen, CC
    Huang, HL
    Chang, CG
    Chen, CF
    Chang, CM
    Hsieh, MT
    PLANTA MEDICA, 2000, 66 (08) : 694 - 698
  • [27] Nucleotide analogs as novel anti-hepatitis B virus agents
    Iyer, RP
    Padmanabhan, S
    Zhang, GR
    Morrey, JD
    Korba, BE
    CURRENT OPINION IN PHARMACOLOGY, 2005, 5 (05) : 520 - 528
  • [28] An overview of anti-Hepatitis B virus flavonoids and their mechanisms of action
    Naderi, Malihe
    Salavatiha, Zahra
    Gogoi, Urvashee
    Mohebbi, Alireza
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2024, 14
  • [29] Anti-hepatitis B virus activity of wogonin in vitro and in vivo
    Guo, Qinglong
    Zhao, Li
    You, Qidong
    Yang, Yong
    Gu, Hongyan
    Song, Guoliang
    Lu, Na
    Xin, Jian
    ANTIVIRAL RESEARCH, 2007, 74 (01) : 16 - 24
  • [30] Panaxadiol and Panaxatriol Derivatives as Anti-Hepatitis B Virus Inhibitors
    Chen H.
    Wang L.-J.
    Ma Y.-B.
    Huang X.-Y.
    Geng C.-A.
    Zhang X.-M.
    Chen J.-J.
    Natural Products and Bioprospecting, 2014, 4 (3) : 163 - 174
12345