Anti-hepatitis B virus active secoiridoids from Swertia kouitchensis

被引：10

作者：

He K. ^{[1
,2
]}

Ma Y.-B. ^{[1
]}

Geng C.-A. ^{[1
]}

Zhang X.-M. ^{[1
]}

Cao T.-W. ^{[1
,2
]}

Jiang F.-Q. ^{[1
,2
]}

Chen J.-J. ^{[1
]}

机构：

[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming

[2] Graduate University of Chinese Academy of Sciences, Beijing

来源：

Natural Products and Bioprospecting | 2011年 / 1卷 / 1期

关键词：

anti-HBV activity; Swertia kouitchensis; swertiakoside A; swertiakoside B; swertiakoulactone;

D O I：

10.1007/s13659-011-0009-5

中图分类号：

学科分类号：

摘要：

Three new secoiridoids, swertiakoulactone (1) and swertiakosides A and B (2 and 3), were isolated from Swertia kouitchensis. Their structures were elucidated by comprehensive spectroscopic analyses including MS, IR, 1D and 2D NMR data. By the anti-hepatitis B virus (HBV) assay on Hep G 2.2.15 cells line in vitro, compound 1 showed moderate activities inhibiting the HBsAg secretion (IC50 = 1.10 mM, SI = 4.39) and HBV DNA replication (IC50 = 1.16 mM, SI = 4.12). [Figure not available: see fulltext.]. © 2011, The Author(s).

引用

页码：48 / 51

页数：3

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