Rad51-mediated double-strand break repair and mismatch correction of divergent substrates

被引：0
|
作者：
Ranjith Anand
Annette Beach
Kevin Li
James Haber
机构：
[1] Brandeis University,Rosenstiel Basic Medical Sciences Research Center and Department of Biology
[2] †Present address: Ginkgo Bioworks,undefined
[3] Boston,undefined
[4] Massachusetts 02210,undefined
[5] USA.,undefined
来源：
Nature | 2017年 / 544卷
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摘要：
DNA repair by break-induced replication begins with the Rad51-mediated invasion of single-stranded DNA into a double-stranded donor template; this study shows that successful recombination between highly mismatched substrates can occur when only five consecutive bases can be paired and that mismatch correction is most efficient near the invading end of the recipient strand.
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页码：377 / 380
页数：3
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