Azole Resistance in Aspergillus fumigatus in Patients with Cystic Fibrosis: A Matter of Concern?

被引：0
作者：
A. Hamprecht
F. Morio
O. Bader
P. Le Pape
J. Steinmann
E. Dannaoui
机构：
[1] University of Cologne,Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne
[2] Université de Nantes,Département de Parasitologie et Mycologie Médicale, EA1155—IICiMed, Institut de Recherche en Santé 2
[3] Nantes Atlantique Universités,Laboratoire de Parasitologie
[4] CHU de Nantes,Mycologie, Institut de Biologie
[5] University Medical Center Göttingen,Institute for Medical Microbiology
[6] University of Duisburg-Essen,Institute of Medical Microbiology, University Hospital Essen
[7] Unité de Parasitologie-Mycologie,Université Paris
[8] Service de Microbiologie,Descartes, Faculté de Médecine, APHP, Hôpital Européen Georges Pompidou
来源：
Mycopathologia | 2018年 / 183卷
关键词：
Azole resistance; Cystic fibrosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Aspergillus fumigatus is the most frequent filamentous fungus isolated from respiratory specimens from patients with cystic fibrosis (CF). Triazoles are the most widely used antifungals in the treatment of allergic bronchopulmonary aspergillosis (ABPA) and invasive aspergillosis (IA) in CF patients. Treatment success could be severely compromised by the occurrence of azole-resistant A. fumigatus (ARAf), which is increasingly reported worldwide from both clinical samples and the environment. In previous studies, ARAf has been detected in up to 8% of CF patients. Isolates from CF patients requiring antifungal treatment should therefore be routinely subjected to antifungal susceptibility testing. The optimal treatment of ABPA or IA in CF patients with azole-resistant isolates has not been established; treatment options include liposomal amphotericin B i.v. and/or echinocandins i.v.
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页码：151 / 160
页数：9
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