The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis

被引：0
作者：
Dinara Afrose
Hao Chen
Amali Ranashinghe
Chia-chi Liu
Annemarie Henessy
Philip M. Hansbro
Lana McClements
机构：
[1] University of Technology Sydney,School of Life Sciences & Institute for Biomedical Materials and Devices (IBMD), Faculty of Science
[2] Centenary Institute,Centre for Inflammation
[3] and University of Technology Sydney,Faculty of Science
[4] Faculty of Science,School of Medicine
[5] University of Colombo,undefined
[6] The Heart Research Institute,undefined
[7] University of Sydney,undefined
[8] Western Sydney University,undefined
[9] Campbelltown Hospital,undefined
[10] South Western Sydney Local Health District,undefined
来源：
Biology of Sex Differences | / 13卷
关键词：
Preeclampsia; Oxidative stress; Heavy metals; Biomarkers; MDA; IMA; Uric acid;
D O I：
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中图分类号：
学科分类号：
摘要：
Biomarkers of oxidative stress are related to the pathogenesis of preeclampsia and might be indicative of evolving preeclampsia and utilized for timely diagnosis and management of preeclampsia.Systematic review and meta-analysis were conducted to evaluate the diagnostic accuracy of oxidative stress markers based on their diagnostic sensitivities and specificities.Clinically relevant positive predictive values (PPVs) and negative predictive values (NPVs) were determined for each biomarker.IMA, UA, and MDA were associated with 3.38, 3.05, and 2.37 odds ratios for preeclampsia onset.IMA exhibited the most promising diagnostic potential with an average PPV of 0.852 and NPV of 0.811, respectively. Minor heterogeneity was reported for these biomarkers (Higgins’ I2 = 0–15.879%).These oxidative stress markers should be further explored in larger cohorts for preeclampsia diagnosis.
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