Assessment of anti-cyclic citrullinated peptide in psoriatic arthritis

被引：12

作者：

Abdel Fattah N.S. ^{[1
]}

Hassan H.E. ^{[2
]}

Galal Z.A. ^{[3
]}

El Okda E.S.E. ^{[4
]}

机构：

[1] Department of Dermatology and Venereology, Faculty of Medicine, Ain Shams University, Cairo

[2] Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo

[3] Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo

[4] Department of Community Medicine, Faculty of Medicine, Ain Shams University, Cairo

来源：

BMC Research Notes | / 2卷 / 1期

关键词：

Rheumatoid Arthritis; Psoriasis; Rheumatoid Arthritis Patient; Rheumatoid Factor; Tender Joint;

D O I：

10.1186/1756-0500-2-44

中图分类号：

学科分类号：

摘要：

Background. Anti-cyclic citrullinated peptides (anti-CCP) are highly specific diagnostic and prognostic markers for rheumatoid arthritis (RA). They have been also found in psoriatic arthritis (PsA), with controversies as regards clinical and radiological associations. The current study assessed anti-CCP in PsA and determined its clinical and radiological associations. Methods. Four groups contributed to this study. 40 PsA, 40 psoriasis without arthritis, 40 RA and 40 healthy controls. They were tested for anti-CCP. Clinical and radiological data were collected and statistically compared between anti-CCP-positive and -negative PsA patients. Results. Seven PsA (17.5%) and 34 RA (85%) were seropositive for anti-CCP. Patients of other groups were anti-CCP-negative. Regarding anti-CCP concentrations, highly significant difference existed between different groups and between anti-CCP-positive and -negative PsA. Significantly higher numbers of involved, swollen and tender joints, deformities and functional impairment of peripheral joints and radiological changes were found in anti-CCP-positive PsA. Conclusion. Anti-CCP may be found in PsA and are associated with higher number of involved, swollen and tender joints, with deformities and functional impairment of peripheral joints and with erosive arthritis. © 2009 Abdel Fattah et al.

引用

共 27 条

[1]

McHugh N.J., Balachrishnan C., Jones S.M., Progression of peripheral joint disease in psoriatic arthritis: A 5-yr prospective study, Rheumatology Oxford, 42, pp. 778-783, (2003)

[2]

Palazzi C., Olivieri I., Petricca A., Salvarani C., Rheumatoid arthritis or psoriatic symmetric polyarthritis? A difficult differential diagnosis, Clin Exp Rheumatol, 20, pp. 3-4, (2002)

[3]

Helliwell P.S., Relationship of psoriatic arthritis with the other spondyloarthropathies, Curr Opin Rheumatol, 16, pp. 344-349, (2004)

[4]

Helliwell P.S., Taylor W.J., Classification and diagnostic criteria for psoriatic arthritis, Annals of the Rheumatic Diseases, 64, SUPPL. 2, (2005)

[5]

Moll J.M.H., Wright V., Psoriatic arthritis, Semin Arthritis Rheum, 3, pp. 55-78, (1973)

[6]

Van Boekel M.A.M., Vossenaar E.R., Van Den Hoogen F.H.J., Van Venrooij W.J., Autoantibody systems in rheumatoid arthritis: Specificity, sensitivity and diagnostic value, Arthritis Research, 4, 2, pp. 87-93, (2002)

[7]

Schellekens G.A., Visser H., De Jong B.A.W., The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide, Arthritis Rheum, 43, pp. 155-163, (2000)

[8]

Bas S., Genevay S., Meyer O., Gabay C., Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis, Rheumatology (Oxford), 42, 5, pp. 677-680, (2003)

[9]

Bizzaro N., Mazzanti G., Tonutti E., Villalta D., Tozzoli R., Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis, Clin Chem, 47, pp. 1089-1093, (2001)

[10]

Krott E., De Jong B.A.W., Van Leeuwen M.A., The prognostic value of anti-cyclic citrullinated peptide antibodies in patients with recent-onset rheumatoid arthritis, Arthritis Rheum, 43, pp. 1831-1835, (2000)

← 1 2 3 →