Cholecystectomy and the Risk of Colorectal Adenomas

被引：0
作者：
Lisa C. Vinikoor
Joseph A. Galanko
Robert S. Sandler
机构：
[1] University of North Carolina,Department of Epidemiology, School of Public Health, and Center for Gastrointestinal Biology and Disease
[2] University of North Carolina,Department of Medicine and Center for Gastrointestinal Biology and Disease, School of Medicine
来源：
Digestive Diseases and Sciences | 2008年 / 53卷
关键词：
Cholecystectomy; Colorectal adenoma; Colorectal cancer; Risk factor; Epidemiology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cholecystectomy has been identified as a risk factor for colorectal cancer, yet little attention has been given to the relationship between cholecystectomy and colorectal adenomas. Utilizing data collected in two large cross-sectional studies of colorectal adenoma risk factors, we examined the association between cholecystectomy and colorectal adenomas. In the adjusted logistic regression model, both men and women showed no effect of cholecystectomy on risk of colorectal adenomas (men: OR 0.67 [95% CI 0.30–1.47]; women: OR 1.46 [95% CI 0.92–2.29]). No effect was seen when examining the time since cholecystectomy for men. There was a slight association found for women who had a cholecystectomy less than 10 years prior (OR 2.02 [95% CI 1.06–3.87]) but no association was seen in women with cholecystectomy at least 10 years prior (OR 1.14 [95% CI 0.62–2.09]). Thus, we conclude that, although cholecystectomy is a risk factor for colorectal cancer, cholecystectomy is not a risk factor for colorectal adenomas.
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页码：730 / 735
页数：5
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  • [1] Urbach DR(2001)Incidence of cancer of the pancreas, extrahepatic bile duct and ampulla of Vater in the United States, before and after the introduction of laparoscopic cholecystectomy Am J Surg 181 526-528
  • [2] Swantstrom LL(1996)Cholecystectomy as a risk factor for colorectal cancer: a meta-analysis Scand J Gastroenterol 31 160-169
  • [3] Khajanchee YS(1993)A meta-analysis of cholecystectomy and risk of colorectal cancer Gastroenterology 105 130-141
  • [4] Hansen PD(2001)Intestinal cancer after cholecystectomy: is bile involved in carcinogenesis? Gastroenterology 121 542-547
  • [5] Reid FDA(1999)Cholecystectomy and the risk of colon cancer Am J Gastroenterol 94 41-46
  • [6] Mercer PM(2004)Risk factors for colorectal cancer: an epidemiologic descriptive study of a series of 333 patients Rom J Gastroenterol 13 187-193
  • [7] Harrison M(2003)Cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas Br J Cancer 88 79-83
  • [8] Bates T(2005)Cholecystectomy and the risk of colorectal cancer Am J Gastroenterol 100 1813-1820
  • [9] Giovannucci E(2003)Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals JAMA 290 2959-2967
  • [10] Colditz GA(1990)A reduced dietary questionnaire: development and validation Epidemiology 1 58-64
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