Old dog, new tricks: IL-6 cluster signaling promotes pathogenic TH17 cell differentiation

被引：0
|
作者：
Francisco J Quintana
机构：
[1] Francisco J. Quintana is with the Ann Romney Center for Neurologic Diseases,
[2] Brigham and Women's Hospital,undefined
[3] Harvard Medical School,undefined
[4] Boston,undefined
[5] Massachusetts,undefined
[6] USA,undefined
[7] and The Broad Institute of MIT and Harvard,undefined
[8] Cambridge,undefined
[9] Massachusetts,undefined
[10] USA.,undefined
来源：
Nature Immunology | 2017年 / 18卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Different cellular sources and signaling mechanisms mediate the effects of IL-6 on the generation of pathogenic TH17 helper T cells and the suppression of Foxp3+ regulatory T cells.
引用
收藏
页码：8 / 10
页数：2
相关论文
共 50 条
  • [1] Old dog, new tricks: IL-6 cluster signaling promotes pathogenic TH17 cell differentiation
    Quintana, Francisco J.
    NATURE IMMUNOLOGY, 2017, 18 (01) : 8 - 10
  • [2] TNFα Promotes Th17 Cell Differentiation through IL-6 and IL-1β Produced by Monocytes in Rheumatoid Arthritis
    Zheng, Yingxia
    Sun, Lei
    Jiang, Ting
    Zhang, Dongqing
    He, Dongyi
    Nie, Hong
    JOURNAL OF IMMUNOLOGY RESEARCH, 2014, 2014
  • [3] Hedgehog signaling pathway regulates Th17 cell differentiation in asthma via IL-6/STAT3 signaling
    Jin, Yuting
    Pan, Zhenzhen
    Zhou, Ji
    Wang, Kai
    Zhu, Peijie
    Wang, Yufeng
    Xu, Xuena
    Zhang, Jinping
    Hao, Chuangli
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 139
  • [4] The A2B Adenosine Receptor Promotes Th17 Differentiation via Stimulation of Dendritic Cell IL-6
    Wilson, Jeffrey M.
    Kurtz, Courtney C.
    Black, Steven G.
    Ross, William G.
    Alam, Mohammed S.
    Linden, Joel
    Ernst, Peter B.
    JOURNAL OF IMMUNOLOGY, 2011, 186 (12): : 6746 - 6752
  • [5] Interleukin-6 (IL-6) trans-presentation is a novel mode of IL-6 signaling that is crucial for the generation of pathogenic Th17 cells
    Garbers, Christoph
    Heink, Sylvia
    Korn, Thomas
    Rose-John, Stefan
    CYTOKINE, 2017, 100 : 110 - 110
  • [6] Tec tyrosine kinase regulates Th17 cell differentiation by quenching IL-6 sensing
    Sandner, Lisa
    Alteneder, Marlis
    Zhu, Ci
    Hladik, Anastasiya
    Hoegler, Sandra
    Van Greuningen, Lars
    Sharif, Omar
    Knapp, Sylvia
    Stockinger, Brigitta
    Kenner, Lukas
    Trauner, Michael
    Ellmeier, Wilfried
    Boucheron, Nicole
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2021, 51 : 141 - 141
  • [7] Tec tyrosine kinase regulates Th17 cell differentiation by quenching IL-6 sensing
    Sandner, L.
    Alteneder, M.
    Hladik, A.
    Van Greuningen, L.
    Sharif, O.
    Knapp, S.
    Ellmeier, W.
    Boucheron, N.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 411 - 411
  • [8] CCR6 intrinsic signaling promotes Th17 cell differentiation during autoimmunity
    Kulkarni, N.
    Lal, G.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 359 - 359
  • [9] Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation
    Jones, Lindsay L.
    Alli, Rajshekhar
    Li, Bofeng
    Geiger, Terrence L.
    JOURNAL OF IMMUNOLOGY, 2016, 196 (07): : 2973 - 2985
  • [10] Inhibition of IL-6 signaling by zinc leads to repression of the Th17 response
    Lee, Won-Woo
    Lee, Hyunju
    Yoon, BoRuem
    Hwang, Yuri
    JOURNAL OF IMMUNOLOGY, 2014, 192
12345