TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiota

被引：0
作者：
Sozaburo Ihara
Yoshihiro Hirata
Kazuhiko Koike
机构：
[1] Asahi Life Foundation,Division of Gastroenterology, The Institute for Adult Diseases
[2] The University of Tokyo,Department of Gastroenterology, Graduate School of Medicine
来源：
Journal of Gastroenterology | 2017年 / 52卷
关键词：
Transforming growth factor-β; Inflammatory bowel disease; Dendritic cells; Microbiota; Adhesion molecules;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Inflammatory bowel disease (IBD) is defined as chronic intestinal inflammation, and includes ulcerative colitis and Crohn’s disease. Multiple factors are involved in the pathogenesis of IBD, and the condition is characterized by aberrant mucosal immune reactions to intestinal microbes in genetically susceptible hosts. Transforming growth factor-β (TGF-β) is an immune-suppressive cytokine produced by many cell types and activated by integrins. Active TGF-β binds to its receptor and regulates mucosal immune reactions through the TGF-β signaling pathway. Dysregulated TGF-β signaling is observed in the intestines of IBD patients. TGF-β signal impairment in specific cell types, such as T-cells and dendritic cells, results in spontaneous colitis in mouse models. In addition, specific intestinal microbes contribute to immune homeostasis by modulating TGF-β production. In this review, we describe the role of TGF-β in intestinal immunity, focusing on immune cells, epithelium, and intestinal microbes. In addition, we present potential therapeutic strategies for IBD that target TGF-β.
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页码：777 / 787
页数：10
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