Multiscale agent-based cancer modeling

被引：0
作者：
Le Zhang
Zhihui Wang
Jonathan A. Sagotsky
Thomas S. Deisboeck
机构：
[1] Harvard-MIT (HST) Athinoula A. Martinos Center for Biomedical Imaging,Complex Biosystems Modeling Laboratory
[2] Massachusetts General Hospital-East 2301,Department of Mathematical Sciences
[3] Michigan Technological University,undefined
来源：
Journal of Mathematical Biology | 2009年 / 58卷
关键词：
Computational systems biology; Agent-based modeling; Tumor simulation; 37N25;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Agent-based modeling (ABM) is an in silico technique that is being used in a variety of research areas such as in social sciences, economics and increasingly in biomedicine as an interdisciplinary tool to study the dynamics of complex systems. Here, we describe its applicability to integrative tumor biology research by introducing a multi-scale tumor modeling platform that understands brain cancer as a complex dynamic biosystem. We summarize significant findings of this work, and discuss both challenges and future directions for ABM in the field of cancer research.
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页码：545 / 559
页数：14
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