Gut microbiota in cancer: insights on microbial metabolites and therapeutic strategies

被引：0
作者：
Yalan Chen
Xibin Wang
Yuwei Ye
Qian Ren
机构：
[1] Lanzhou University,The First School of Clinical Medicine
[2] The First Hospital of Lanzhou University,Department of Gastroenterology
[3] Lanzhou University,Gansu Province Clinical Research Center for Digestive Diseases
来源：
Medical Oncology | / 41卷
关键词：
Gut microbiota; Metabolites; Cancer; Probiotics; Fecal microbiota transplantation; Chemotherapy; Radiotherapy; Immunotherapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In recent years, the role of gut microbiota in cancer treatment has attracted substantial attention. It is now well established that gut microbiota and its metabolites significantly contribute to the incidence, treatment, and prognosis of various cancers. This review provides a comprehensive review on the pivotal role of gut microbiota and their metabolites in cancer initiation and progression. Furthermore, it evaluates the impact of gut microbiota on the efficacy and associated side effects of anticancer therapies, including radiotherapy, chemotherapy, and immunotherapy, thus emphasizing the clinical importance of gut microbiota reconstitution in cancer treatment.
引用
收藏
相关论文
共 630 条
[1]  
Brown EM(2013)The role of the immune system in governing host microbe interactions in the intestine Nat Immunol 14 660-667
[2]  
Sadarangani M(2015)Cancer and the microbiota Science 348 80-86
[3]  
Finlay BB(2021)The microbiome and human cancer Science. 371 eabc4552-22
[4]  
Garrett WS(2021)Gut microbiota-derived metabolites in colorectal cancer: the bad and the challenges Front Oncol 18 739648-235
[5]  
Sepich-Poore GD(2021)Human gut microbiota in health and selected cancers Int J Mol Sci 22 13440-1964
[6]  
Zitvogel L(2022)Global research trends on the links between the gut microbiome and cancer: a visualization analysis J Transl Med 20 83-802
[7]  
Straussman R(2021)The interplay between Helicobacter pylori and gastrointestinal microbiota Gut Microbes 13 1-672
[8]  
Hasty J(2022)The role of key gut microbial metabolites in the development and treatment of cancer Gut Microbes 14 2038865-626
[9]  
Wargo JA(2023)A review of gut microbiota-derived meabolites in tumor progression and cancer therapy Adv Sci Weinh Baden-Wurtt Ger 10 e2207366-299
[10]  
Knight R(2021)Short chain fatty acids and its producing organisms: an overlooked therapy for IBD? EBioMedicine 66 103293-6
12345678910