Novel Blood-Based Biomarkers for HCC

被引：0
作者：
Pai, Suraj [1 ]
Parikh, Neehar D. [1 ,2 ]
机构：
[1] Univ Michigan, Dept Internal Med, 1500 Med Ctr Dr, Ann Arbor, MI 48104 USA
[2] Univ Michigan, Div Gastroenterol & Hepatol, Ann Arbor, MI 48104 USA
来源：
CURRENT HEPATOLOGY REPORTS | 2024年 / 23卷 / 01期
关键词：
Hepatocellular carcinoma; Biomarkers; Cancer screening; HEPATOCELLULAR-CARCINOMA SURVEILLANCE; GAMMA-CARBOXY PROTHROMBIN; SERUM ALPHA-FETOPROTEIN; PATIENT-REPORTED BARRIERS; HIGH-SENSITIVITY; RISK-FACTORS; HEPATITIS-C; CANCER; DIAGNOSIS; VALIDATION;
D O I：
10.1007/s11901-023-00626-3
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Purpose of ReviewHepatocellular carcinoma (HCC) is a leading cause of cancer mortality. Early detection is crucial for improving patient survival. This review summarizes research on novel biomarkers for HCC, outlining the steps necessary prior to their use in clinical practice.Recent FindingsThe most commonly used biomarker used for HCC, alpha-fetoprotein (AFP), has limited sensitivity and specificity for early detection. Recent advances have identified several novel candidates such as AFP-L3, des-gamma carboxyprothrombin (DCP), and cell-free DNA (cfDNA), which can be used independently or incorporated into algorithms such as the GALAD score to improve diagnostic utility.SummaryValidation of reliable novel biomarkers for HCC can improve early detection, and ultimately survival in patients with HCC.
引用
收藏
页码：174 / 184
页数：11
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