Coumarin and 3,4-dihydroquinolinone derivatives: Synthesis, antidepressant activity, and molecular docking studies

被引：0
作者：
Shi-Ben Wang
Hui Liu
Guang-Yong Li
Jun Li
Xiao-Jing Li
Kang Lei
Li-Chao Wei
Zhe-Shan Quan
Xue-Kun Wang
Ren-Min Liu
机构：
[1] Liaocheng University,College of Pharmacy
[2] Liaocheng University,College of Life Sciences
[3] Yanbian University,College of Pharmacy
来源：
Pharmacological Reports | 2019年 / 71卷
关键词：
Coumarin; 3,4-Dihydroquinolinone; Molecular docking studies; Antidepressant; 5-HT;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: Coumarin and 3,4-dihydroquinolinone nuclei are two heterocyclic rings that are important and widely exploited for the development of bioactive molecules. Here, we designed and synthesized a series of 3,4-dihydroquinolinone and coumarin derivatives (Compounds 8,9,11,14,15,18-20, 23, 24 and 28 are new compounds) and studied their antidepressant activities.
引用
收藏
页码：1244 / 1252
页数：8
相关论文
共 162 条
  • [31] Chen Y(2019)Dysfunctional attitudes and 5-HT Comput Biol Chem 78 108-34
  • [32] Xu X(1977) receptors during depression self-harm J Am Chem Soc 99 8127-33
  • [33] Qiu Y(2003)5-HT Drug Discov Today 8 927-61
  • [34] Liu S(2007) and 5-HT Nature Rev Drug Discov 6 650-53
  • [35] Liu X(2005) receptors affinity, docking studies and pharmacological evaluation of a series of 8-acetyl-7-hydroxy-4- methylcoumarin derivatives NeuroRx 2 541-undefined
  • [36] Jayagobi M(undefined)Is there a role for 5-HT undefined undefined undefined-undefined
  • [37] Raghunathan R(undefined) agonists in the treatment of depression? undefined undefined undefined-undefined
  • [38] Sainath S(undefined)Molecular docking, dynamics simulations and 3D-QSAR modeling of arylpiperazine derivatives of 3,5-dioxo-(2 undefined undefined undefined-undefined
  • [39] Raghunathan M(undefined),4 undefined undefined undefined-undefined
  • [40] Xiao Z(undefined))-1,2,4-triazine as 5-HT undefined undefined undefined-undefined
12345678910