Coumarin and 3,4-dihydroquinolinone derivatives: Synthesis, antidepressant activity, and molecular docking studies

被引：0
作者：
Shi-Ben Wang
Hui Liu
Guang-Yong Li
Jun Li
Xiao-Jing Li
Kang Lei
Li-Chao Wei
Zhe-Shan Quan
Xue-Kun Wang
Ren-Min Liu
机构：
[1] Liaocheng University,College of Pharmacy
[2] Liaocheng University,College of Life Sciences
[3] Yanbian University,College of Pharmacy
来源：
Pharmacological Reports | 2019年 / 71卷
关键词：
Coumarin; 3,4-Dihydroquinolinone; Molecular docking studies; Antidepressant; 5-HT;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: Coumarin and 3,4-dihydroquinolinone nuclei are two heterocyclic rings that are important and widely exploited for the development of bioactive molecules. Here, we designed and synthesized a series of 3,4-dihydroquinolinone and coumarin derivatives (Compounds 8,9,11,14,15,18-20, 23, 24 and 28 are new compounds) and studied their antidepressant activities.
引用
收藏
页码：1244 / 1252
页数：8
相关论文
共 162 条
  • [11] Vida M(2015)The chemistry and biological activity of heterocycle-fused quinolinone derivatives: a review Eur J Med Chem 97 397-408
  • [12] Perez-Cruz K(2005)Synthesis of 6-alkyloxyl-3,4-dihydro-2(1 B Korean Chem Soc 26 1757-60
  • [13] Moncada-Basualto M(2009))-quinoliones and their anticonvulsant activities Mini Rev Med Chem 9 1648-54
  • [14] Morales-Valenzuela J(2012)Biological activities of quinoline derivatives Med Chem Res 21 3692-8
  • [15] Barriga-Gonzalez G(2011)Synthesis and study of the antidepressant activity of novel 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[l,5-a]quinoline derivatives Eur J Med Chem 46 670-5
  • [16] Navarrete-Encina P(2018)Synthesis, antidepressant and antifungal evaluation of novel 2-chloro-8-methylquinoline amine derivatives Molecules 23 153-92
  • [17] Nunez-Vergara L(2014)Novel 6- and 7-Substituted coumarins with inhibitory action against Lipoxygenase and tumor-associated carbonic anhydrase IX Iran J Pharm Res 13 881-74
  • [18] Sashidhara KV(2015)Synthesis and biological investigation of some novel sulfonamide and amide derivatives containing coumarin moieties Eur J Med Chem 106 60-34
  • [19] Modukuri RK(2013)Novel oxime- bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model Eur J Med Chem 59 227-3
  • [20] Singh S(2017)Synthesis and antiproliferative activities of Bioorg Med Chem Lett 27 5420-36
12345678910