Coumarin and 3,4-dihydroquinolinone derivatives: Synthesis, antidepressant activity, and molecular docking studies

被引：0
作者：
Shi-Ben Wang
Hui Liu
Guang-Yong Li
Jun Li
Xiao-Jing Li
Kang Lei
Li-Chao Wei
Zhe-Shan Quan
Xue-Kun Wang
Ren-Min Liu
机构：
[1] Liaocheng University,College of Pharmacy
[2] Liaocheng University,College of Life Sciences
[3] Yanbian University,College of Pharmacy
来源：
Pharmacological Reports | 2019年 / 71卷
关键词：
Coumarin; 3,4-Dihydroquinolinone; Molecular docking studies; Antidepressant; 5-HT;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: Coumarin and 3,4-dihydroquinolinone nuclei are two heterocyclic rings that are important and widely exploited for the development of bioactive molecules. Here, we designed and synthesized a series of 3,4-dihydroquinolinone and coumarin derivatives (Compounds 8,9,11,14,15,18-20, 23, 24 and 28 are new compounds) and studied their antidepressant activities.
引用
收藏
页码：1244 / 1252
页数：8
相关论文
共 162 条
  • [1] Grahek I(2019)Motivation and cognitive control in depression Neurosci Biobehav Rev 102 371-81
  • [2] Shenhav A(2013)Oleoylethanolamide dose-dependently attenuates cocaine-induced behaviours through a PPARαreceptor-independent mechanism Addict Biol 18 78-87
  • [3] Musslick S(2018)Synthesis and antioxidant study of new polyphenolic hybrid-coumarins Arab J Chem 11 525-37
  • [4] Krebs RM(2015)Design and synthesis of new series of coumarin-aminopyran derivatives possessing potential anti-depressant-like activity Bioorg Med Chem Lett 25 337-41
  • [5] Koster EHW(2014)Synthesis and evaluation of new 3-phenylcoumarin derivatives as potential antidepressant agents Bioorg Med Chem Lett 24 4876-80
  • [6] Bilbao A(2014)Synthesis and biological evaluation of a novel sigma-1 receptor antagonist based on 3,4-dihydro-2(lH)-quinolinones caffold as a potential analgesic Eur J Med Chem 79 216-30
  • [7] Blanco E(2011)Synthesis and antibacterial property of pyrrolopyrano quinolinones and pyrroloquinolines Eur J Med Chem 46 2075-82
  • [8] Luque-Rojas MJ(2001)Design and synthesis of Pfmrk inhibitors as potential antimalarial agents Bioorg Med Chem Lett 11 2875-8
  • [9] Suarez J(2018)Sulfamic acid promoted one-pot synthesis of phenanthrene fused-dihydrodibenzo-quinolinones: Anticancer activity, tubulin polymerization inhibition and apoptosis inducing studies Bioorg Med Chem Lett 26 1996-2008
  • [10] Palomino A(2002)3-Ary1-2-quinolone derivatives: synthesis and characterization of in vitro and in vivo antitumor effects with emphasis on a new therapeutical target connected with cell migration J Med Chem 45 2543-55
12345678910