Resveratrol reverses the negative effect of alcohol on hydroxyapatite-coated implant osseointegration in senile female rats; [Resveratrol kehrt den negativen Effekt von Alkohol auf die Osseointegration hydroxylapatitbeschichteter Implantate bei alten weiblichen Ratten um]

被引：0
作者：
Tao Z.-S. [1 ]
Zhou W.-S. [2 ]
Yang M. [1 ]
Xu H. [3 ]
机构：
[1] Department of Trauma orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 2, Zhe shan Xi Road, Wuhu, 241001, Anhui
[2] Department of Geriatrics, The Second Affiliated Hospital of Wannan Medical College, Yijishan Hospital, No. 10, Rehabilitation Road, Wuhu, 241001, Anhui
[3] Dept of Spine Surgery, Yijishan hospital of Wannan Medical College, No. 2, Zhe shan Xi Road, Wuhu, 241001, Anhui
来源：
Zeitschrift für Gerontologie und Geriatrie | 2020年 / 53卷 / 6期
关键词：
Alcohol; Bone loss; Osseointegration; Resveratrol;
D O I：
10.1007/s00391-019-01595-3
中图分类号：
学科分类号：
摘要：
Previous studies have demonstrated the damaging effect of alcohol (ALH) consumption on bone tissue and bone metabolism. Resveratrol (RES) promotes osteoblast proliferation and inhibits osteoclast proliferation and positively affects bone regeneration; however, reports about effects of RES on osseointegration in aged female rats with ALH consumption are limited. This study was designed to investigate the impact of treatment with RES on osseointegration for aged female rats with ALH consumption. This study included 30 female Sprague-Dawley rats (22 months old), weighing approximately 520 g. All animals were randomly divided into 3 groups of 10: a control group (CON) receiving saline, a group receiving ALH and a group receiving ALH + RES until death after 12 weeks. The results of enhanced osseointegration in senile female rats with RES consumption were evaluated by histology, microcomputerized tomography (micro-CT), gene expression analysis and a biomechanical test. The results of this study indicated that ALH + RES showed stronger effects on the improvement of osseointegration in senile female rats with ALH consumption. The ALH + RES produced stronger effects on bone volume per total volume (BV/TV), mean trabecular thickness (Tb.Th), mean trabecular number (Tb.N) and mean trabecular separation (Tb.Sp), connective tissue density (Conn.D) and maximum push-out force for implants, and regulation of osteogenesis and bone resorption-related gene expression. These results seem to indicate that RES intervention reverses the negative effect of alcohol on hydroxyapatite-coated implant osseointegration in senile female rats with ALH consumption. © 2019, Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
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页码：538 / 545
页数：7
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