Immunogenic cell death (ICD)-inducers in non-small-cell lung carcinoma (NSCLC): current knowledge and future perspective

被引：0
作者：
Alireza Kashefizadeh
Hossein Kazemizadeh
机构：
[1] Shahid Beheshti University of Medical Sciences,Department of Pulmonology, Shahid Labbafinejad Hospital
[2] Tehran University of Medical Sciences,Advanced Thoracic Research Center
来源：
Clinical and Translational Oncology | 2023年 / 25卷
关键词：
Immunogenic cell death; Immunotherapy; Lung cancer; NSCLC;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The prevalence of non-small-cell lung cancer (NSCLC) is rising every year all around the world. The interaction between cancer cells and the tumor microenvironment (TME) is a crucial factor in determining the development of human neoplasms. Organellar and cellular stress are induced during immunogenic cell death (ICD), a particularly functional response pattern. ICD is a separate but poorly characterized entity caused by various cancer treatments. The induction of ICD has the potential to change TME and the recruitment of tumor-infiltrating lymphocytes (TILs), and the coupling of ICD-inducers and other therapeutic approaches can have a synergistic role in boosting anticancer impacts. The purpose of this study is to review the studies in the field of NSCLC using ICD-inducers as a treatment strategy or as a combination therapy. This review provide for researches a better view of what has been done so far and the challenges they face in the future.
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页码：316 / 322
页数：6
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