Synthesis of Modified Peptides with C-Terminal α-Amino Aldehydes

被引：0
作者：
J. V. Potetinova
E. I. Milgotina
V. A. Makarov
T. L. Voyushina
机构：
[1] Institute of Genetics and Selection of Industrial Microorganisms,Stepanov Laboratory of Protein Chemistry
[2] Hematology Research Center,Laboratory of Pharmacology and Pathology of Hemostasis
来源：
Russian Journal of Bioorganic Chemistry | 2001年 / 27卷
关键词：
peptide aldehydes; chemical synthesis; enzyme synthesis; protease inhibitors;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Various synthetic approaches to modified peptides with the C-terminal aldehyde group, capable of inhibiting a number of proteolytic enzymes belonging to the classes of thiol, serine, and aspartyl proteases, are considered. Both chemical methods, including solid phase peptide synthesis now widely used, and biocatalytic synthetic methods for obtaining these substances are discussed in detail.
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页码：141 / 150
页数：9
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