Adherence to Oral and Topical Medications in Cutaneous Lupus Erythematosus is not Well Characterized

被引：13
作者：
Farhangian M.E. [1 ]
Huang W.W. [1 ]
Feldman S.R. [2 ,3 ]
机构：
[1] Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Winston-Salem, NC
[2] Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC
[3] Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC
来源：
Dermatology and Therapy | 2015年 / 5卷 / 2期
关键词：
Adherence; Compliance; Corticosteroids; Cutaneous lupus erythematosus (CLE); Hydroxychloroquine; Sunscreen; Systemic lupus erythematosus (SLE); Topical medications;
D O I：
10.1007/s13555-015-0075-4
中图分类号：
学科分类号：
摘要：
Introduction: Treatment adherence plays a large role in chronic dermatologic diseases and may play an important role in the outcomes of patients with cutaneous lupus erythematosus (CLE). We sought to gauge what is currently known about adherence to topical and oral medications in patients with CLE. Methods: A review of MEDLINE was performed using a combination of the phrases “adherence”, “compliance”, “lupus”, and “cutaneous”. Studies were hand searched and prospective and cross-sectional studies evaluating medication adherence in patients with CLE and systemic lupus erythematosus (SLE) were included. Results: Only two articles explored adherence in patients with CLE, while 17 articles discussed treatment adherence in patients with SLE. Depression was consistently cited as detrimental to adherence. The impact that race, ethnicity, and education has on adherence is unclear. Three studies noted a clear connection between adherence and disease activity, while two others did not. Few studies investigated methods that have improved adherence to treatment which have showed promise. Conclusion: Much of what we know about adherence to medication in patients with lupus is limited to SLE. Although cutaneous symptoms are among the most common manifestations of SLE, cutaneous disease is often managed at least in part with topical agents, and adherence to topical treatment was not assessed in any of the articles, though one study investigated sunscreen usage in patients with CLE. Understanding adherence in patients with CLE may help contribute to better CLE treatment outcomes. © 2015, The Author(s).
引用
收藏
页码：91 / 105
页数：14
相关论文
共 39 条
[1]  
Verma S.M., Okawa J., Propert K.J., Werth V.P., The impact of skin damage due to cutaneous lupus on quality of life, Br J Dermatol, 170, 2, pp. 315-321, (2014)
[2]  
Ezra N., Jorizzo J., Hydroxychloroquine and smoking in patients with cutaneous lupus erythematosus, Clin Exp Dermatol, 37, 4, pp. 327-334, (2012)
[3]  
Chang A.Y., Werth V.P., Treatment of cutaneous lupus, Curr Rheumatol Rep, 13, 4, pp. 300-307, (2011)
[4]  
Benner J.S., Glynn R.J., Mogun H., Neumann P.J., Weinstein M.C., Avorn J., Long-term persistence in use of statin therapy in elderly patients, JAMA, 288, 4, pp. 455-461, (2002)
[5]  
Richards H.L., Fortune D.G., O'Sullivan T.M., Main C.J., Griffiths C.E., Patients with psoriasis and their compliance with medication, J Am Acad Dermatol, 41, 4, pp. 581-583, (1999)
[6]  
Carroll C.L., Feldman S.R., Camacho F.T., Manuel J.C., Balkrishnan R., Adherence to topical therapy decreases during the course of an 8-week psoriasis clinical trial: commonly used methods of measuring adherence to topical therapy overestimate actual use, J Am Acad Dermatol, 51, 2, pp. 212-216, (2004)
[7]  
Conlon N.P., Edgar J.D., Adherence to best practice guidelines in chronic spontaneous urticaria (CSU) improves patient outcome, Eur J Dermatol, 24, 3, pp. 385-386, (2014)
[8]  
Torrelo A., Ortiz J., Alomar A., Ros S., Pedrosa E., Cuervo J., Health-related quality of life, patient satisfaction, and adherence to treatment in patients with moderate or severe atopic dermatitis on maintenance therapy: the CONDA-SAT study, Actas Dermosifiliogr, 104, 5, pp. 409-417, (2013)
[9]  
Zschocke I., Mrowietz U., Karakasili E., Reich K., Non-adherence and measures to improve adherence in the topical treatment of psoriasis, J Eur Acad Dermatol Venereol, 28, pp. 4-9, (2014)
[10]  
Rothfield N., Sontheimer R.D., Bernstein M., Lupus erythematosus: systemic and cutaneous manifestations, Clin Dermatol, 24, 5, pp. 348-362, (2006)
1234