Antibiotics and pneumology

被引：0

作者：

Lorenz J. ^{[1
]}

Kern W.V. ^{[2
]}

Halle E. ^{[3
]}

Grabein B. ^{[4
]}

机构：

[1] Klinik für Pneumologie und Internistische Intensivmedizin Infektiologie, Schlafmedizin, Klinikum Lüdenscheid, 58515 Lüdenscheid

[2] Zentrum Infektiologie und Reisemedizin, Medizinische Klinik, Universitätsklinikum Freiburg, Freiburg

[3] Institut für Mikrobiologie und Hygiene, Charité Universitätsmedizin, Berlin

[4] Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Universitätsklinikum Großhadern, München

来源：

Der Pneumologe | 2006年 / 3卷 / 1期

关键词：

Antimicrobial resistance; Antimicrobials; Pharmacodynamics; Pharmacokinetics; Respiratory tract infections;

D O I：

10.1007/s10405-005-0076-6

中图分类号：

学科分类号：

摘要：

Antibiotics are antibacterial drugs which interfere with bacterial biology in multiple ways, inhibition of bacterial protein biosynthesis being their most common mechanism of action. The rules that govern bactericidal activity in vivo (pharmacodynamics), as well as drug absorption, distribution and elimination within the host (pharmacokinetics), are essential for the clinical activity of antibiotics. Parameters and data that describe antibacterial activity are introduced in this article. Knowledge of these rules supports the selection of the appropriate antimicrobial and the choice of the correct dosage. Treatment failures may be the consequence of natural bacterial resistance. However, many organisms possess multiple mechanisms of genetic rearrangement or acquisition of foreign genetic material with the possible consequence of escape after antibacterial challenge. Resistant clones may be selected during every treatment. The prevalence of acquired resistance is currently still relatively favourable in Germany in comparison to international data. © Springer Medizin Verlag 2005.

引用

页码：59 / 76

页数：17

共 9 条

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