Usage of polymer brushes as substrates of bone cells

被引：7
作者：
Sabine A. Letsche
Annina M. Steinbach
Manuela Pluntke
Othmar Marti
Anita Ignatius
Dirk Volkmer
机构：
[1] Ulm University,Institute of Inorganic Chemistry II
[2] Ulm University,Institute of Experimental Physics
[3] Ulm University,Institute of Orthopaedic Research and Biomechanics
来源：
Frontiers of Materials Science in China | 2009年 / 3卷 / 2期
关键词：
polymer brush; ATRP; micropatterning; bone cell; cell adhesion;
D O I：
10.1007/s11706-009-0035-y
中图分类号：
学科分类号：
摘要：
Implant medical research and tissue engineering both target the design of novel biomaterials for the improvement of human health and clinical applications. In order to develop improved surface coatings for hard tissue (bone) replacement materials and implant devices, we are developing micropatterned coatings consisting of polymer brushes. These are used as organic templates for the mineralization of calcium phosphate in order to improve adhesion of bone cells. First, we give a short account of the current state-of-the-art in this particular field of biomaterial development, while in the second part the preliminary results of cell culture experiments are presented, in which the biocompatibility of polymer brushes are tested on human mesenchymal stem cells.
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页码：132 / 144
页数：12
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