Efficacy and safety of anakinra in tumor necrosis factor receptor-associated periodic syndrome (TRAPS) complicated by severe renal failure: a report after long-term follow-up and review of the literature

被引：0
作者：
Stefano Gentileschi
Donato Rigante
Antonio Vitale
Jurgen Sota
Bruno Frediani
Mauro Galeazzi
Luca Cantarini
机构：
[1] University of Siena,Research Center of Systemic Autoinflammatory Diseases, Behçet’s Disease Clinic and Rheumatology
[2] Università Cattolica Sacro Cuore,Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences
[3] Fondazione Policlinico Universitario “A. Gemelli”,Institute of Pediatrics
[4] Policlinico “Le Scotte”,undefined
来源：
Clinical Rheumatology | 2017年 / 36卷
关键词：
Anakinra; Autoinflammatory diseases; gene; TRAPS; Treatment;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS), caused by mutations in the TNFRSF1A gene, is the most frequent autosomal dominant autonflammatory disease displaying a relevant risk of reactive AA amyloidosis, if left untreated. Our report deals with one adult with TRAPS complicated by amyloidosis-related renal failure, treated with the recombinant human interleukin-1 receptor antagonist anakinra at a higher than conventional dosage. This treatment did not present any adverse event and led remarkably to the disappearance of all TRAPS-related manifestations and prompt decrease of laboratory abnormalities, including proteinuria. A review of the medical literature has been also considered to evaluate efficacy and safety of interleukin-1 inhibition in patients with TRAPS.
引用
收藏
页码：1687 / 1690
页数：3
相关论文
共 189 条
  • [1] Williamson LM(1982)Familial Hibernian fever Q J Med 51 469-480
  • [2] Hull D(2014)Key facts and hot spots on tumor necrosis factor receptor-associated periodic syndrome Clin Rheumatol 33 1197-1207
  • [3] Mehta R(2013)From the Mediterranean to the sea of Japan: the transcontinental odyssey of autoinflammatory diseases Biomed Res Int 2013 485103-900
  • [4] Reeves WG(2014)The hereditary autoinflammatory disorders uncovered Autoimmun Rev 13 892-2167
  • [5] Robinson BH(2014)The phenotype of TNF receptor-associated autoinflammatory syndrome (TRAPS) at presentation: a series of 158 cases from the Eurofever/EUROTRAPS international registry Ann Rheum Dis 73 2160-27
  • [6] Toghill PJ(2017)A systematic approach to autoinflammatory syndromes: a spelling booklet for the beginner Expert Rev Clin Immunol 9 1-43
  • [7] Rigante D(2014)Untangling the web of systemic autoinflammatory diseases Mediat Inflamm 2014 948154-1644
  • [8] Lopalco G(2012)Tumour necrosis factor receptor-associated periodic syndrome (TRAPS): state of the art and future perspectives Autoimmun Rev 12 38-685
  • [9] Vitale A(2015)Recommendations for the management of autoinflammatory diseases Ann Rheum Dis 74 1636-891
  • [10] Lucherini OM(2013)Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review Ann Rheum Dis 72 678-707
12345678910