Rosacea fulminans, pyostomatitis and pyovulvitis in Crohn's disease: Dapsone as key factor in combination therapy?

被引：10
作者：
Gatzka M. [1 ]
Simon M. [1 ]
Schuler G. [1 ]
Lüftl M. [1 ,2 ]
机构：
[1] Hautklinik, Universitätsklinikum Erlangen
[2] Hautklinik, Universitätsklinikum Erlangen, 91052 Erlangen
来源：
Der Hautarzt | 2006年 / 57卷 / 10期
关键词：
Dapsone; Granulomatous cheilitis; Isotretinoin; Mucocutaneous Crohn's disease; Rosacea;
D O I：
10.1007/s00105-005-1017-3
中图分类号：
学科分类号：
摘要：
Rosacea fulminans (also known as pyoderma faciale) has been reported to occur in association with Crohn's disease. It is still unclear whether the papulopustules and confluent nodules of rosacea fulminans represent a manifestation of mucocutaneous Crohn's disease or whether this association is a mere coincidence. A 46-year-old woman presented with the spontaneous outbreak of rosacea fulminans and pyostomatitis/pyovulvitis. Complete remission of the mucocutaneous symptoms was achieved with 2 months combination therapy with methylprednisolone, isotretinoin and dapsone. The patient's Crohn's disease, already diagnosed for 3 years, did not flare during this period. © 2006 Springer Medizin Verlag.
引用
收藏
页码：898 / 902
页数：4
相关论文
共 10 条
  • [1] Bormann G., Gaber G., Fischer M., Marsch W.C., Dapsone in rosacea fuminans, J Eur Acad Dermatol Venereol, 15, pp. 465-467, (2001)
  • [2] Djawari D., Vulvitis granulomatosa bei Morbus Crohn, Akt Dermatol, 30, pp. 77-80, (2004)
  • [3] Georgala S., Katoulis A.C., Kylafis G.D., Et al., Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea, J Eur Acad Dermatol Venereol, 15, pp. 441-444, (2001)
  • [4] Glanz S., Maceyko R.F., Camisa C., Tomecki K.J., Mucocutaneous presentations of Crohn's disease, Cutis, 47, pp. 167-172, (1991)
  • [5] Jansen T., Plewig G., Kligman A.M., Diagnosis and treatment of rosacea fulminans, Dermatology, 188, pp. 251-254, (1994)
  • [6] Jansen T., Plewig G., Fulminating rosacea conglobata (rosacea fulminans) and ulcerative colitis, Br J Dermatol, 137, pp. 830-831, (1997)
  • [7] Jansen T., Plewig G., Klinische Studien zur systemischen Therapie der Rosacea, Rosacea - Klinik und Aktuelle Therapie, pp. 51-61, (2003)
  • [8] McHenry P.M., Hudson M., Smart L.M., Et al., Pyoderma faciale in a patient with Crohn's disease, Clin Exp Dermatol, 17, pp. 460-462, (1992)
  • [9] Rosen T., Unkefer R.P., Treatment of pyoderma faciale with isotretinoin in a patient with ulcerative colitis, Cutis, 64, pp. 107-109, (1999)
  • [10] Wozel G., Wirkungsmechanismen von Dapson, Dapson, pp. 24-48, (1996)
1