Bioavailability of coenzyme Q10 in various pharmaceutical formulations

被引：0
作者：
E. I. Kalenikova
E. A. Gorodetskaya
O. S. Medvedev
机构：
[1] Moscow State University,Department of Basic Medicine
来源：
Pharmaceutical Chemistry Journal | 2009年 / 43卷
关键词：
coenzyme Q; pharmacokinetics; solubilized substance;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The bioavailability of coenzyme Q10(CoQ10) in various pharmaceutical formulations (solutions and tablets) containing solubilized CoQ10 in comparison to lipophilic powder of CoQ10 has been studied in rats. It is established that the bioavailability of solubilized CoQ10 in tablets and solution after peroral administration is higher than that of lipophilic CoQ10 powder. The time to reach peak CoQ10 concentrations in plasma was shorter for the solution of the solubilized form. Auxiliary swelling substances in tablets prolong and increase the absorption of CoQ10.
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页码：468 / 471
页数：3
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