Epstein-Barr virus is absent in gastric superficial neoplastic lesions

被引：0
作者：
Joana Ribeiro
Mariana Malta
Ana Galaghar
Luís Pedro Afonso
Diogo Libânio
Rui Medeiros
Mario Dinis-Ribeiro
Pedro Pimentel-Nunes
Hugo Sousa
机构：
[1] Portuguese Oncology Institute of Porto,Molecular Oncology & Viral Pathology Group (CI
[2] FMUP,IPOP)
[3] Research Department,Faculty of Medicine of Porto University
[4] Portuguese League Against Cancer (Liga Portuguesa Contra o Cancro-Núcleo Regional do Norte),Department of Pathology
[5] Portuguese Oncology Institute of Porto,Gastroenterology Department
[6] Portuguese Oncology Institute of Porto,CINTESIS
[7] Universidade do Porto, Center for Health Technology and Services Research (Centro de Investigação Médica, Faculdade de Medicina
[8] Portuguese Oncology Institute of Porto,Virology Service
[9] University of Minho,Life and Health Sciences Research Institute (ICVS), School of Health Sciences
[10] Campus de Gualtar,undefined
[11] ICVS/3B’s - PT Government Associate Laboratory,undefined
来源：
Virchows Archiv | 2019年 / 475卷
关键词：
Gastric dysplasia; Neoplastic lesion; Gastric cancer; Epstein-Barr virus (EBV); EBVaGC;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Epstein-Barr virus (EBV) has been associated with about 9% of all gastric carcinomas, but its role in gastric carcinogenesis remains unclear since there is lack of evidence of EBV presence in pre-neoplastic lesions of gastric mucosa. This study intends to determine the prevalence of EBV in gastric dysplasia and superficial neoplasia to clarify whether EBV infection is an early or late event in gastric cancer development. This retrospective study included a total of 242 gastric lesions from 199 consecutive patients who were referred for endoscopic resection. The histological classification of lesions includes 137 low- and high-grade dysplasia and 105 superficial carcinomas. EBV infection was investigated by EBER-ISH. Results showed that EBV was not detected in any epithelial cells of any case with dysplasia or superficial carcinomas, although we observed the presence of a small number of EBV-infected lymphocytes in 2.1% of all lesions. These results showed that EBV is not present in gastric dysplasia neither in superficial carcinomas suggesting that EBV carcinogenesis is a late event in well/moderately differentiated gastric carcinogenesis.
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页码：757 / 762
页数：5
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共 278 条
  • [1] Burke AP(1990)Lymphoepithelial carcinoma of the stomach with Epstein-Barr virus demonstrated by polymerase chain reaction Mod Pathol 3 377-380
  • [2] Yen TS(2016)Anti-helicobacter pylori antibody profiles in Epstein-Barr virus (EBV)-positive and EBV-negative gastric cancer Helicobacter 21 153-157
  • [3] Shekitka KM(2014)Improved survival of gastric cancer with tumour Epstein-Barr virus positivity: an international pooled analysis Gut 63 236-243
  • [4] Sobin LH(2011)Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis Br J Cancer 105 38-43
  • [5] Camargo MC(2014)Comprehensive molecular characterization of gastric adenocarcinoma Nature 513 202-209
  • [6] Kim KM(2007)Epstein-Barr virus gastritis: an underrecognized form of severe gastritis simulating gastric lymphoma Am J Surg Pathol 31 1446-1451
  • [7] Matsuo K(2014)Occurrence of Helicobacter pylori and Epstein-Barr virus infection in endoscopic and gastric cancer patients from Northern Brazil BMC gastroenterology 14 179-179
  • [8] Torres J(2012)Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED) Endoscopy 44 74-94
  • [9] Liao LM(2002)Gastrointestinal epithelial neoplasia: Vienna revisited Gut 51 130-131
  • [10] Morgan DR(1996)Classification and grading of gastritis. The updated Sydney System. International workshop on the histopathology of gastritis, Houston 1994 Am J Surg Pathol 20 1161-1181
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