Histomorphometric Analysis and Markers of Endometrial Receptivity Embryonic Implantation in Women With Polycystic Ovary Syndrome During the Treatment With Progesterone

被引：0

作者：

Ione Maria Ribeiro Soares Lopes

Carla Cristina Maganhin

Ricardo Martins Oliveira-Filho

Ricardo Santos Simões

Manuel Jesus Simões

Margareth Chiharu Iwata

Edmund Chada Baracat

José Maria Soares

机构：

[1] Universidade Federal do Piauí,Departamento Materno Infantil, Centro de Ciências da Saúde

[2] UFPI,Departamento de Ginecologia, Departamento de Ginecologia

[3] Escola Paulista de Medicina,Departamento de Farmacologia, Instituto de Ciências Biomédicas

[4] Universidade Federal de São Paulo,Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia

[5] EPM/UNIFESP,undefined

[6] Universidade de São Paulo,undefined

[7] USP,undefined

[8] Faculdade de Medicina da Universidade de São Paulo,undefined

[9] FMUSP,undefined

来源：

Reproductive Sciences | 2014年 / 21卷

关键词：

polycystic ovary syndrome; endometrium; cell adhesion molecules;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Literature data indicate that the infertility in women with polycystic ovary syndrome (PCOS) is not only attributed to anovulation but also to endometrial dysfunction. Endometrial biopsies were performed in the proliferative and secretory phases of women with normal cycle and in women with PCOS before and after oral treatment with micronized progesterone. After the treatment, the endometrium of the women with PCOS exhibited a lower number of glands and thicker luminal epithelium compared to the normal women in the secretory phase. In addition, the PCOS group exhibited reduced integrin and MECA-79 immunoexpression during the secretory phase. The expression of E-cadherin was higher in the PCOS and the expression of intercellular adhesion molecule 1 was lower in PCOS, during the secretory and proliferative phases, respectively. Also, there is a negative correlation with MECA-79 and integrin expression and body mass index. Conventional doses of progesterone may not be enough to correct the changes of endometrial histomorphology and the receptive markers of PCOS-bearing women. The obesity may be a factor that interferes with this response.

引用

页码：930 / 938

页数：8

共 139 条

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