Enhancement and Comparison of (Ceftazidime-)Avibactam Plus Aztreonam Susceptibility Tests for Stenotrophomonas maltophilia in Clinical Diagnostics

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作者：
Gro L. Vlaspolder
Laura A. Hughes
Robert A. G. Huis in ’t Veld
Greetje A. Kampinga
Erik Bathoorn
机构：
[1] University of Groningen,Department of Medical Microbiology and Infection Prevention, University Medical Centre Groningen
来源：
Current Microbiology | 2024年 / 81卷
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摘要：
Stenotrophomonas maltophilia is naturally resistant to many antimicrobials. We evaluated the in vitro activity and reproducibility of two different super-position methods of aztreonam in combination with ceftazidime-avibactam for S. maltophilia and compared these results with the recently available aztreonam-avibactam gradient strip. We recommend an improved super-position method that avoids the possible risk of handling a contaminated aztreonam strip. In addition, we report that the cefazidime-avibactam and aztreonam super-position method showed increased in vitro activity in comparison with aztreonam-avibactam indicating activity of the ceftazidime component in vitro.
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