Sustained, Controlled and Stimuli-Responsive Drug Release Systems Based on Nanoporous Anodic Alumina with Layer-by-Layer Polyelectrolyte

被引：0
作者：
Maria Porta-i-Batalla
Chris Eckstein
Elisabet Xifré-Pérez
Pilar Formentín
J. Ferré-Borrull
Lluis F. Marsal
机构：
[1] Universitat Rovira i Virgili,Department of Electronic, Electric and Automatics Engineering
来源：
Nanoscale Research Letters | 2016年 / 11卷
关键词：
Drug delivery; Electrochemical anodization; Nanoporous alumina; Stimuli-responsive release; Doxorubicin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Controlled drug delivery systems are an encouraging solution to some drug disadvantages such as reduced solubility, deprived biodistribution, tissue damage, fast breakdown of the drug, cytotoxicity, or side effects. Self-ordered nanoporous anodic alumina is an auspicious material for drug delivery due to its biocompatibility, stability, and controllable pore geometry. Its use in drug delivery applications has been explored in several fields, including therapeutic devices for bone and dental tissue engineering, coronary stent implants, and carriers for transplanted cells. In this work, we have created and analyzed a stimuli-responsive drug delivery system based on layer-by-layer pH-responsive polyelectrolyte and nanoporous anodic alumina. The results demonstrate that it is possible to control the drug release using a polyelectrolyte multilayer coating that will act as a gate.
引用
收藏
相关论文
共 88 条
  • [1] Sinn Aw M(2014)Non-eroding drug-releasing implants with ordered nanoporous and nanotubular structures: concepts for controlling drug release Biomater Sci 2 10-34
  • [2] Kurian M(2009)Self-ordered nanopore and nanotube platforms for drug delivery applications Expert Opin Drug Deliv 6 1363-1381
  • [3] Losic D(2007)Drug delivery strategies for poorly water-soluble drugs Expert Opin Drug Deliv 4 403-16
  • [4] Losic D(2015)A facile route for rapid synthesis of hollow mesoporous silica nanoparticles as pH-responsive delivery carrier J Colloid Interface Sci 451 101-107
  • [5] Simovic S(2015)A highly controllable electrochemical anodization process to fabricate porous anodic aluminum oxide membranes Nanoscale Res Lett 10 495-5187
  • [6] Fahr A(2007)Controlled drug release using nanoporous anodic aluminum oxide on stent Thin Solid Films 515 5184-674
  • [7] Liu X(2011)Hierarchical nanoporous anodic alumina templates by asymmetric two-step anodization Phys Status Solidi (a) 208 668-18608
  • [8] Xu H(2012)Structural tuning of photoluminescence in nanoporous anodic alumina by hard anodization in oxalic and malonic acids Nanoscale Res Lett 7 228-32
  • [9] Zhang H(2015)In vitro biocompatibility of surface-modified porous alumina particles for HepG2 tumor cells: toward early diagnosis and targeted treatment ACS Appl Mater Interfaces 7 18600-9
  • [10] Wang D(2015)Mesoporous alumina as a biomaterial for biomedical applications Mesoporous Biomaterials 2 13-708
123456789