A New Xenograft Model of Primary Central Nervous System Lymphoma

被引：0
作者：
Marco Saini
Mattia Bellinzona
Wiebke Weichhold
Madjid Samii
机构：
[1] Nordstadt Hospital,Department of Neurosurgery, Center for Experimental Neurooncology
[2] Nordstadt Hospital,Institute of Pathology
来源：
Journal of Neuro-Oncology | 1999年 / 43卷
关键词：
brain; lymphoma; model; nude; rat;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The management of primary lymphoma of the central nervous system (PCNSL) remains controversial and patients' outcome dismal. In order to investigate new selective therapeutic strategies in a controlled system, a reproducible model of PCNSL in nude rats was developed and characterized. Human B lymphoma cells (BL2) were implanted in the brain frontal area in New Zealand nude rats through a silastic device sealed to the skull. Fifteen and 30 days post-implantation, animals were sacrificed. An autopsy was performed. Representative brain sections were cut and examined for the presence of lymphoma. Immunohistochemistry was performed for proliferation (MIB1-Ki67), a B-cell marker (L26-CD20), a T-cell marker (UCHL1-CD45RO).
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页码：153 / 160
页数：7
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