Successful double bypass in a patient with severe hemophilia A: a case report

被引:0
作者
Giovanni Barillari
Samantha Pasca
Filippo Erice
Ugolino Livi
机构
[1] University Hospital of Udine,Center for Hemorrhagic and Thrombotic Diseases
[2] University Hospital,Anesthesia and Resuscitation Department
[3] University Hospital,Cardiac Surgery Department
来源
Journal of Thrombosis and Thrombolysis | 2012年 / 33卷
关键词
Cardiovascular surgery; Hemophilia A; Haemostasis; FVIII replacement;
D O I
暂无
中图分类号
学科分类号
摘要
Life expectancy in the hemophilia people is similar to the non–haemophilics and age-related cardiovascular disorders to become more prevalent, but cardiac surgery is considered a very high risk for these patients. In this article we report the successful cardiac double bypass internal mammary artery—coronary artery in a patient with severe hemophilia A. (FVIII<1%; missense mutation: exon 16, c.5508 G>A (domain A3), p.Trp1817Stop). Continuous infusion of rFVIII B-domain deleted was used to control haemostasis during surgery and in post-operative period. There was no bleeding complications and the patient did not need to receive transfusion of red blood cells or platelets.
引用
收藏
页码:193 / 196
页数:3
相关论文
共 56 条
[1]  
Tang M(2009)Cardiac surgery in patients with haemophilia Haemophilia 15 101-107
[2]  
Wierup P(2006)Cardiac surgery in a patient with haemophilia A Thorac Cardiov Surg 54 212-214
[3]  
Terp K(2009)Coronary artery bypass surgery, angioplasty and long term anti-platelet treatment in a type B hemophilia patient Clinics 64 822-2414
[4]  
Ingerslev J(2007)Tranexamic acid combined with recombinant factor VIII increases clot resistance to accelerated fibrinolysis in severe hemophilia A J Thromb Haemost 5 2408-458
[5]  
Sørensen B(2004)Continuous infusion of B-domain deleted recombinant factor VIII (ReFacto) in patients with haemophilia A undergoing surgery: clinical experience Haemophilia 10 452-1236
[6]  
Eren A(2003)Intensive exposure to factor VIII is a risk factor for inhibitor development in mild hemophilia A J Thromb Haemost 1 1228-281
[7]  
Friedl R(2011)Influence of the type F8 mutation on inhibitor development in a single centre cohort of haemophilia A patients Haemophilia 17 275-141
[8]  
Hannekum A(2008)Transient acquired hemophilia associated with J Korean Med Sci 23 138-453
[9]  
Gulbins H(2008) Pneumoniae Chest 133 381-undefined
[10]  
Pesaro AE(undefined)American college chest physicians. Prevention of thromboembolism: American college of chest physicians: evidence-based clinical practice guidelines (8th Edition) undefined undefined undefined-undefined