Structural polymorphism and solubility of medicinal drugs (Using Perindopril as an Example)

被引：0

作者：

N. Yu. Bogdanov

K. A. Gorchakov

V. S. Puchnin

V. A. Stepanov

V. S. Khmelevskaya

机构：

[1] National Nuclear Research University,Obninsk Institute for Nuclear Power Engineering, Moscow Engineering Physics Institute

来源：

Crystallography Reports | 2011年 / 56卷

关键词：

Dioxane; Crystallography Report; Perindopril; Polymor Phism; Chloride Methylene;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The correlation between the structural polymorphism of perindopril salt C19H32N2O5 · C4H11N and its bioavailability has been investigated. During the crystallization of perindopril salt from an organic solvent, a low-symmetry perindopril polymorph is formed when the most polar solvent is used. It is shown that the dissolution rate in water, which is a measure of the bioavailability of any pharmaceutical product, is higher for the perindopril salt grown from the least polar solvent and that the structure has a monoclinic symmetry.

引用

页码：608 / 610

页数：2

共 6 条

[1] Structural polymorphism and solubility of medicinal drugs (Using Perindopril as an Example)
Bogdanov, N. Yu.
Gorchakov, K. A.
Puchnin, V. S.
Stepanov, V. A.
Khmelevskaya, V. S.
CRYSTALLOGRAPHY REPORTS, 2011, 56 (04) : 608 - 610
[2] Polymorphism of Carbamazepine Pharmaceutical Cocrystal: Structural Analysis and Solubility Performance
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PHARMACEUTICS, 2023, 15 (06)
[3] Structural and functional state of left ventricle and efficacy of an angiotensin converting enzyme perindopril in patients with heart failure after myocardial infarction: Relation to angiotensin converting enzyme gene polymorphism
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Ishikawa, E
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[6] Analysis of the effect of the bovine adenosine triphosphate-binding cassette transporter G2 single nucleotide polymorphism Y581S on transcellular transport of veterinary drugs using new cell culture models
Real, R.
Gonzalez-Lobato, L.
Baro, M. F.
Valbuena, S.
de la Fuente, A.
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Alvarez, A. I.
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JOURNAL OF ANIMAL SCIENCE, 2011, 89 (12) : 4325 - 4338

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