Clinical trials for breast cancer with brain metastases: Challenges and new directions

被引：4
作者：
Morikawa A. [1 ]
Jhaveri K. [2 ]
Seidman A.D. [1 ]
机构：
[1] Breast Cancer Medicine Service, Memorial Sloan-Kettering Cancer Center, 300 E 66th Street, New York
[2] New York University Cancer Institute, New York
来源：
Current Breast Cancer Reports | 2013年 / 5卷 / 4期
关键词：
Brain metastases; Breast cancer; Clinical trials; Epidemiology; Management; Prognostic factors; Radiation-induced radiologic changes; Screening and diagnosis; Systemic therapy; Tissue analysis;
D O I：
10.1007/s12609-013-0120-1
中图分类号：
学科分类号：
摘要：
Brain metastases (BM) portend a poor prognosis among breast cancer patients. The management of breast cancer with brain metastases (BCBM) is multi-modal with local therapy consisting of radiation and/or surgery, albeit without durable responses, and systemic therapy playing an increasingly important role. Further clinical research is warranted to improve prognosis for BCBM. However, there are several challenges in studying this population. This review provides a general overview of BCBM and discusses unique aspects of conducting clinical trials and ongoing/future research in BCBM. © 2013 Springer Science+Business Media New York.
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收藏
页码：293 / 301
页数：8
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