Clinical trials for breast cancer with brain metastases: Challenges and new directions

被引：4
作者：
Morikawa A. [1 ]
Jhaveri K. [2 ]
Seidman A.D. [1 ]
机构：
[1] Breast Cancer Medicine Service, Memorial Sloan-Kettering Cancer Center, 300 E 66th Street, New York
[2] New York University Cancer Institute, New York
来源：
Current Breast Cancer Reports | 2013年 / 5卷 / 4期
关键词：
Brain metastases; Breast cancer; Clinical trials; Epidemiology; Management; Prognostic factors; Radiation-induced radiologic changes; Screening and diagnosis; Systemic therapy; Tissue analysis;
D O I：
10.1007/s12609-013-0120-1
中图分类号：
学科分类号：
摘要：
Brain metastases (BM) portend a poor prognosis among breast cancer patients. The management of breast cancer with brain metastases (BCBM) is multi-modal with local therapy consisting of radiation and/or surgery, albeit without durable responses, and systemic therapy playing an increasingly important role. Further clinical research is warranted to improve prognosis for BCBM. However, there are several challenges in studying this population. This review provides a general overview of BCBM and discusses unique aspects of conducting clinical trials and ongoing/future research in BCBM. © 2013 Springer Science+Business Media New York.
引用
收藏
页码：293 / 301
页数：8
相关论文
共 80 条
[1]  
Brufsky, A.M., Mayer, M., Rugo, H.S., Kaufman, P.A., Tan-Chiu, E., Tripathy, D., Central nervous system metastases in patients with HER2-positive metastatic breast cancer: Incidence, treatment, and survival in patients from registHER (2011) Clin Cancer Res, 17, pp. 4834-4843. , 10.1158/1078-0432.CCR-10-2962 21768129 10.1158/1078-0432.CCR-10-2962 1:CAS:528:DC%2BC3MXovFehtLs%3D
[2]  
Nieder, C., Spanne, O., Mehta, M.P., Grosu, A.L., Geinitz, H., Presentation, patterns of care, and survival in patients with brain metastases: What has changed in the last 20 years? (2010) Cancer, , 10.1002/cncr.25707
[3]  
Graesslin, O., Abdulkarim, B.S., Coutant, C., Huguet, F., Gabos, Z., Hsu, L., Nomogram to predict subsequent brain metastasis in patients with metastatic breast cancer (2010) J Clin Oncol, 28, pp. 2032-2037. , 10.1200/JCO.2009.24.6314 20308667 10.1200/JCO.2009.24.6314
[4]  
Pivot, X.S.V., Zurawski, B., Allerton, R., Fabi, A., Ciruelos, E., Parikh, R., (2012) CEREBEL (EGF111438): An Open Label Randomized Phase III Study Comparing the Incidence of CNS Metastases in Patients (Pts) with HER2+ Metastatic Breast Cancer (MBC), Treated with Lapatinib Plus Capecitabine (LC) Vs Trastuzumab Plus Capecitabine (TC), , (eds) et al. The Annual Meeting of the European Society for Medical Oncology Vienna This study showed a high prevalence of asymptomatic BM among HER2+ BC patient
[5]  
Lin, N.U., Winer, E.P., Brain metastases: The HER2 paradigm (2007) Clinical Cancer Research, 13 (6), pp. 1648-1655. , http://clincancerres.aacrjournals.org/cgi/reprint/13/6/1648.pdf, DOI 10.1158/1078-0432.CCR-06-2478
[6]  
Larsen, P.B., Kumler, I., Nielsen, D.L., A systematic review of trastuzumab and lapatinib in the treatment of women with brain metastases from HER2-positive breast cancer (2013) Cancer Treat Rev, , 10.1016/j.ctrv.2013.01.006 23481218
[7]  
Tsao, M.N., Rades, D., Wirth, A., Lo, S.S., Danielson, B.L., Gaspar, L.E., Radiotherapeutic and surgical management for newly diagnosed brain metastasis/es: An American Society for Radiation Oncology evidence-based guideline (2012) (2012) Clinical Practice Guideline, , https://http://www.astro.org/Clinical-Practice/Guidelines/ Brain-metastases.aspx, The American Society for Radiation Oncology (ASTRO) Accessed June 18 2013
[8]  
Sperduto, P.W., Kased, N., Roberge, D., Chao, S.T., Shanley, R., Luo, X., The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer (2013) J Neurooncol, , 10.1007/s11060-013-1083-9 23462853 This study provides prognostic information according to subtypes for patients with BCBM undergoing RT using "Sperduto" model
[9]  
Niwinska, A., Tacikowska, M., Murawska, M., The effect of early detection of occult brain metastases in HER2-positive breast cancer patients on survival and cause of death (2010) Int J Radiat Oncol Biol Phys, 77, pp. 1134-1139. , 10.1016/j.ijrobp.2009.06.030 19932944 10.1016/j.ijrobp.2009.06.030
[10]  
Lin, N.U., Brain metastases in HER2-positive breast cancer (2013) Lancet Oncol, 14, pp. 185-186. , 10.1016/S1470-2045(13)70046-9 23414590 10.1016/S1470-2045(13)70046-9
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