A matrixA issign-regular if, for each orderk, allk×k submatrices ofA have determinant with the same sign. In this paper, a pivoting strategy ofO(n) operations for the Gaussian elimination of linear systems whose coefficient matrices are sign-regular is proposed. Backward error analysis of this pivoting strategy is performed and small error bounds are obtained. Our results can also be applied to linear systems whose coefficient matrices have sign-regular inverses.