Toxicity and potential utility of ivermectin and moxidectin as xenointoxicants against the common bed bug, Cimex lectularius L.

被引:0
作者
Johnathan M. Sheele
Gale E. Ridge
机构
[1] University Hospitals Case Medical Center and Case Western Reserve University,Department of Emergency Medicine
[2] The Connecticut Agricultural Experiment Station,undefined
来源
Parasitology Research | 2016年 / 115卷
关键词
Ivermectin; Moxidectin; Bed bug; Mortality; Treatment; Xenointoxication;
D O I
暂无
中图分类号
学科分类号
摘要
The recent resurgence of the common bed bug Cimex lectularius L. throughout western industrialized nations has been facilitated in part by the insect becoming pesticide-resistant. Novel control strategies, including xenointoxication, should be considered to combat C. lectularius. Ivermectin, a U.S. Food and Drug Administration (FDA)-approved treatment for several human parasites, and the antiparasitic drug moxidectin, currently being explored in human clinical trials, were evaluated for efficacy against C. lectularius. Results showed that C. lectularius fed on ivermectin or moxidectin blood concentrations of >25 ng/mL and had significantly higher mortality (50–100 %) than controls (0–6 %) by day 13. Bed bugs that survived a blood meal containing >2.5 ng/mL of ivermectin suffered long-term sequelae including reduced fecundity, feeding difficulty, and incomplete ecdysis. Some insects that survived a blood meal containing ≤75 ng/mL moxidectin were able to feed and reproduce.
引用
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页码:3071 / 3081
页数:10
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