Telocytes in the Myocardium of Children with Congenital Heart Disease Tetralogy of Fallot

被引：0
作者：
T. V. Sukhacheva
N. V. Nizyaeva
M. V. Samsonova
A. L. Chernyaev
A. I. Shchegolev
R. A. Serov
机构：
[1] Ministry of Health of Russian Federation,A. N. Bakulev National Medical Research Center of Cardiovascular Surgery
[2] Ministry of Health of Russian Federation,V. I. Kulakov National Research Medical Center for Obstetrics, Gynecology and Perinatology
[3] Federal Medical-Biological Agency of Russian Federation,Research Institute of Pulmonology
来源：
Bulletin of Experimental Biology and Medicine | 2020年 / 169卷
关键词：
children’s myocardium; tetralogy of Fallot; telocytes; ultrastructure; immunohistochemistry;
D O I：
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中图分类号：
学科分类号：
摘要：
Telocytes, a new type of interstitial stem cells with long thin processes that form a three-dimensional network around cardiomyocytes, vessels, and nerve fibers were described in the myocardium of children with tetralogy of Fallot. Two types of morphologically different telocytes, spindle-shaped and rounded, were identified. Contacts of telocytes with stem cells and interstitial macrophages were found. Telocytes were more common in the immature myocardium, where the assembly of myofibrils in cardiomyocytes was not completed and small Ki-67+ cardiomyocyte progenitor cells were present. Telocytes expressed immunohistochemical markers CD117, vimentin, CD34, and CD44. Localization and ultrastructural characteristics of telocytes suggested their participation in stem cell differentiation, coordination of neoangiogenesis, and paracrine regulation of all components of the interstitium.
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页码：137 / 146
页数：9
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