Breast cancer risk–associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression

被引：0
作者：
Richard Cowper-Sal·lari
Xiaoyang Zhang
Jason B Wright
Swneke D Bailey
Michael D Cole
Jerome Eeckhoute
Jason H Moore
Mathieu Lupien
机构：
[1] Norris Cotton Cancer Center,Department of Genetics
[2] Dartmouth Medical School,Department of Medical Biophysics
[3] Institute for Quantitative Biomedical Sciences,undefined
[4] Norris Cotton Cancer Center,undefined
[5] Dartmouth Medical School,undefined
[6] Ontario Cancer Institute,undefined
[7] Princess Margaret Hospital–University Health Network,undefined
[8] University of Toronto,undefined
[9] Institut National de la Santé et de la Recherche Médicale (INSERM),undefined
[10] Unité Mixte de Recherche (UMR) 1011,undefined
[11] Université de Lille Nord de France,undefined
[12] Institut Pasteur de Lille,undefined
来源：
Nature Genetics | 2012年 / 44卷
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D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mathieu Lupien, Jason Moore and colleagues show that breast cancer risk–associated SNPs commonly disrupt the binding of FOXA1 to chromatin, thereby directly affecting gene expression.
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页码：1191 / 1198
页数：7
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