Hypoglycemic, hypolipidemic and antioxidant properties of combination of Curcumin from Curcuma longa, Linn, and partially purified product from Abroma augusta, Linn. in streptozotocin induced diabetes

被引：71
作者：
Ali Hussain H.E.M. [1 ]
机构：
[1] C/o Dr. Paul Ratnaswamy, National Chemical Laboratory
来源：
Indian Journal of Clinical Biochemistry | 2002年 / 17卷 / 2期
关键词：
Abroma augusta; Antioxidants; Curcumin; Diabetes mellitus; Hypoglycemia; Hypolipidemic effect; Lipid peroxidation;
D O I：
10.1007/BF02867969
中图分类号：
学科分类号：
摘要：
Dietary spice components of Curcuma longa and Abroma augusta have been screened for their protective effect against reactive oxygen species induced lipid peroxidation. They have been found to be efficient antioxidant when administered in combination. The purpose of the study was to investigate the effect of oral administration (300 mg / Kg) of the aqueous extract of turmeric whose active ingredient is Curcumin and Abromine powder as a hypoglycemic agent mixed with diet. The effect of this aqueous extract on blood glucose, lipid peroxidation (LPO) and the antioxidant defense system in rat tissues like liver, lung, kidney and brain was studied for 8 weeks in streptozotocin induced diabetic rats. The administration of an aqueous extract of turmeric and abromine powder resulted in a significant reduction in blood glucose and an increase in total haemoglobin. The aqueous extract also resulted in decreased free radical formation in the tissues studied. The decrease in thiobarbituric acid reactive substances (TBARS) and increase in reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) clearly showed the antioxidant property of the mixture. It is suggested that these changes initially counteract the oxidative stress in diabetes however, a gradual decrease in the antioxidative process may be one of the factors which results in chronic diabetes. These results indicate that the mixture of the two plants have shown antidiabetic activity and also reduced oxidative stress in diabetes.A combination of Abroma augusta and Curcuma longa also restored the other general parameters in diabetic animals. The results were statistically analyzed and indicated that combination of herbal extracts showed better efficacy as compared to individual herbal plant extracts used.
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页码：33 / 43
页数：10
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