Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells

被引:0
作者
Kazuaki Nomura
Kazufumi Obata
Takashi Keira
Ryo Miyata
Satoshi Hirakawa
Ken-ichi Takano
Takayuki Kohno
Norimasa Sawada
Tetsuo Himi
Takashi Kojima
机构
[1] Sapporo Medical University School of Medicine,Departments of Otolaryngology
[2] Sapporo Medical University School of Medicine,Departments of Pathology
[3] Sapporo Medical University School of Medicine,Departments of Pediatrics
[4] Research Institute for Frontier Medicine,Department of Cell Science
[5] Sapporo Medical University School of Medicine,undefined
来源
Respiratory Research | / 15卷
关键词
elastase; Tight junctions; Barrier function; Human nasal epithelial cells; Signal transduction; PAR-2;
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  • [1] Dulon S(2005)Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells Am J Respir Cell Mol Biol 32 411-419
  • [2] Leduc D(2011)Inhibition of protein kinase C attenuates Pseudomonas aeruginosa elastase-induced epithelial barrier disruption Am J Respir Cell Mol Biol 45 1263-1271
  • [3] Cottrell GS(2013)Allergic rhinitis and chronic rhinosinusitis: their impact on lower airways Immunol Allergy Clin North Am 33 45-60
  • [4] D’Alayer J(1985)Role of Pseudomonas aeruginosa exoenzymes in lung infections of patients with cystic fibrosis Infect Immun 49 557-562
  • [5] Hansen KK(1997)Correlation of Pseudomonas aeruginosa virulence factors from clinical and environmental isolates with pathogenicity in the neutropenic mouse Can J Microbiol 43 541-551
  • [6] Bunnett NW(2000)Virulence factors from Pseudomonas aeruginosa increase lung epithelial permeability Lung 178 261-269
  • [7] Hollenberg MD(2002)Pseudomonas aeruginosa elastase stimulates ERK signaling pathway and enhances IL-8 production by alveolar epithelial cells in culture Inflamm Res 51 506-510
  • [8] Pidard D(2007)The Pseudomonas aeruginosa LasB metalloproteinase regulates the human urokinase-type plasminogen activator receptor through domain-specific endoproteolysis Infect Immun 75 3848-3858
  • [9] Chignard M(2010)Activation of human pro-urokinase by unrelated proteases secreted by Pseudomonas aeruginosa Biochem J 428 473-482
  • [10] Clark CA(2008)A novel secreted protease from Pseudomonas aeruginosa activates NF-kappaB through protease-activated receptors Cell Microbiol 10 1491-1504