Rosiglitazone Ameliorates Diabetic Nephropathy by Reducing the Expression of Chemerin and ChemR23 in the Kidney of Streptozotocin-Induced Diabetic Rats

被引：0
作者：
Wenchao Hu
Qian Yu
Jie Zhang
Demin Liu
机构：
[1] Tianjin Medical University,Department of Metabolism, General Hospital
[2] Tianjin Medical University,Department of Laboratory, Metabolic Disease Hospital
来源：
Inflammation | 2012年 / 35卷
关键词：
chemerin; ChemR23; diabetic nephropathy; rosiglitazone; pioglitazone; inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. This study aims to determine whether rosiglitazone and pioglitazone ameliorate renal function through an effect on the expression of chemerin and ChemR23 in streptozotocin-induced diabetic rats. The rats were randomized to control, diabetic, rosiglitazone-, and pioglitazone-treated groups. The expression level of chemerin and ChemR23 in the renal tissues was significantly elevated in the diabetic group compared with the control group. Rosiglitazone inhibited the overexpression of chemerin and ChemR23, while pioglitazone inhibited the overexpression of ChemR23 in the kidney of diabetic rats. In addition, chemerin expression level was positively correlated with transforming growth factor-β1, connective tissue growth factor, tumor necrosis factor-α, and intracellular cell adhesion molecule-1 expression in diabetic rats. Rosiglitazone ameliorates diabetic nephropathy by reducing the expression of chemerin and ChemR23 in diabetic rats.
引用
收藏
页码：1287 / 1293
页数：6
相关论文
共 197 条
[1]  
Wagman AS(2001)Current therapies and emerging targets for the treatment of diabetes Current Pharmaceutical Design 7 417-450
[2]  
Nuss JM(2010)Serum levels of the adipokine chemerin in relation to renal function Diabetes Care 33 171-173
[3]  
Pfau D(2010)Clinical importance of an elevated circulating chemerin level in incident dialysis patients Nephrology, Dialysis, Transplantation 25 4017-4023
[4]  
Bachmann A(2010)Elevated serum chemerin concentrations are associated with renal dysfunction in type 2 diabetic patients Diabetes Research and Clinical Practice 91 159-163
[5]  
Lössner U(2009)Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis European Journal of Endocrinology 161 339-344
[6]  
Kratzsch J(2010)Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes Clinical Endocrinology 72 342-348
[7]  
Blüher M(2008)The role of inflammatory cytokines in diabetes and its complications Journal of Periodontology 79 1527-1534
[8]  
Stumvoll M(2007)Chemerin–a new adipokine that modulates adipogenesis via its own receptor Biochemical and Biophysical Research Communications 362 1013-1038
[9]  
Fasshauer M(2011)Chemokine-like receptor 1 (CMKLR1) and chemokine (C-C motif) receptor-like 2 (CCRL2); two multifunctional receptors with unusual properties Experimental Cell Research 317 674-684
[10]  
Yamamoto T(2001)Insulin resistance and its treatment by thiazolidinediones Recent Progress in Hormone Research 56 265-294
12345678910